Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Feb;65(2):300–303. doi: 10.1073/pnas.65.2.300

Brain Function and Macromolecules, VI. Autoradiographic Analysis of the Effect of a Brief Training Experience on the Incorporation of Uridine into Mouse Brain*

Barry E Kahan 1,2,3,†, Martin R Krigman 1,2,3, John Eric Wilson 1,2,3,‡, Edward Glassman 1,2,3,§
PMCID: PMC282901  PMID: 5263766

Abstract

In agreement with the data of Beach et al. (these Proceedings, 62, 692 (1969)) on the effects of avoidance training on protein synthesis, we report autoradiographic evidence for the increased incorporation of radioactive uridine into limbic system structures of the brains of trained mice. There is also a decreased incorporation into the outer layers of the neocortex. The observed responses in labeling are restricted to the nuclei of neurons. The significance of these changes in brain function is not known but they may be related to those processes of the memory consolidation phenomenon affected by inhibitors of protein and RNA synthesis.

Full text

PDF
300

Images in this article

302Image
on p.302

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Adair L. B., Wilson J. E., Glassman E. Brain function and macromolecules, IV. Uridine incorporation into polysomes of mouse brain during different behavioral experiences. Proc Natl Acad Sci U S A. 1968 Nov;61(3):917–922. doi: 10.1073/pnas.61.3.917. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Adair L. B., Wilson J. E., Zemp J. W., Glassman E. Brain function and macromolecules. 3. Uridine incorporation into polysomes of mouse brain during short-term avoidance conditioning. Proc Natl Acad Sci U S A. 1968 Oct;61(2):606–613. doi: 10.1073/pnas.61.2.606. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Beach G., Emmens M., Kimble D. P., Lickey M. Autoradiographic demonstration of biochemical changes in the limbic system during avoidance training. Proc Natl Acad Sci U S A. 1969 Mar;62(3):692–696. doi: 10.1073/pnas.62.3.692. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Glassman E. The biochemistry of learning: an evaluation of the role of RNA and protein. Annu Rev Biochem. 1969;38:605–646. doi: 10.1146/annurev.bi.38.070169.003133. [DOI] [PubMed] [Google Scholar]
  5. Zemp J. W., Wilson J. E., Glassman E. Brain function and macromolecules. II. Site of increased labeling of RNA in brains of mice during a short-term training experience. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1120–1125. doi: 10.1073/pnas.58.3.1120. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Zemp J. W., Wilson J. E., Schlesinger K., Boggan W. O., Glassman E. Brain function and macromolecules. I. Incorporation of uridine into RNA of mouse brain during short-term training experience. Proc Natl Acad Sci U S A. 1966 Jun;55(6):1423–1431. doi: 10.1073/pnas.55.6.1423. [DOI] [PMC free article] [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES