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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Feb;65(2):310–317. doi: 10.1073/pnas.65.2.310

Hamster-Tropic Sarcomagenic and Nonsarcomagenic Viruses Derived from Hamster Tumors Induced by the Gross Pseudotype of Moloney Sarcoma Virus*

Gary Kelloff 1,2,, Robert J Huebner 1,2,, Yong Ki Lee 1,2,, Robert Toni 1,2,, Raymond Gilden 1,2
PMCID: PMC282903  PMID: 4984233

Abstract

Hamster sarcomas induced by the Gross pseudotype of Moloney sarcoma virus yielded a virus sarcomagenic for hamsters but not mice. This virus was able to produce foci on hamster embryo cells, but not on mouse embryo cells. A hamster-tropic nonfocus-forming helper virus was also found in the viral stocks. These hamster-tropic viruses are not immunologically related to the murine viruses in the original inoculum but appear to represent indigenous C-type RNA viruses of the hamster.

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Selected References

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  1. Bassin R. H., Simons P. J., Chesterman F. C., Harvey J. J. Murine sarcoma virus (Harvey): characteristics of focus formation in mouse embryo cell cultures, and virus production by hamster tumor cells. Int J Cancer. 1968 Mar 15;3(2):265–272. doi: 10.1002/ijc.2910030212. [DOI] [PubMed] [Google Scholar]
  2. Duesberg P. H., Robinson W. S. Nucleic acid and proteins isolated from the Rauscher mouse leukemia virus (MLV). Proc Natl Acad Sci U S A. 1966 Jan;55(1):219–227. doi: 10.1073/pnas.55.1.219. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Geering G., Old L. J., Boyse E. A. Antigens of leukemias induced by naturally occurring murine leukemia virus: their relation to the antigens of gross virus and other murine leukemia viruses. J Exp Med. 1966 Oct 1;124(4):753–772. doi: 10.1084/jem.124.4.753. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Graffi A., Schramm T., Bender E., Graffi I., Horn K. H., Bierwolf D. Cell-free transmissible leukoses in Syrian hamsters, probably of viral aetiology. Br J Cancer. 1968 Sep;22(3):577–581. doi: 10.1038/bjc.1968.68. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. Gregoriades A., Old L. J. Isolation and some characteristics of a group-specific antigen of the murine leukemia viruses. Virology. 1969 Feb;37(2):189–202. doi: 10.1016/0042-6822(69)90198-6. [DOI] [PubMed] [Google Scholar]
  6. HUEBNER R. J., ROWE W. P., TURNER H. C., LANE W. T. SPECIFIC ADENOVIRUS COMPLEMENT-FIXING ANTIGENS IN VIRUS-FREE HAMSTER AND RAT TUMORS. Proc Natl Acad Sci U S A. 1963 Aug;50:379–389. doi: 10.1073/pnas.50.2.379. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Hanafusa H., Hanafusa T. Further studies on RSV production form transformed cells. Virology. 1968 Apr;34(4):630–636. doi: 10.1016/0042-6822(68)90084-6. [DOI] [PubMed] [Google Scholar]
  8. Hartley J. W., Rowe W. P., Capps W. I., Huebner R. J. Complement fixation and tissue culture assays for mouse leukemia viruses. Proc Natl Acad Sci U S A. 1965 May;53(5):931–938. doi: 10.1073/pnas.53.5.931. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Hartley J. W., Rowe W. P., Capps W. I., Huebner R. J. Isolation of naturally occurring viruses of the murine leukemia virus group in tissue culture. J Virol. 1969 Feb;3(2):126–132. doi: 10.1128/jvi.3.2.126-132.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Hartley J. W., Rowe W. P. Production of altered cell foci in tissue culture by defective Moloney sarcoma virus particles. Proc Natl Acad Sci U S A. 1966 Apr;55(4):780–786. doi: 10.1073/pnas.55.4.780. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Huebner R. J., Hartley J. W., Rowe W. P., Lane W. T., Capps W. I. Rescue of the defective genome of Moloney sarcoma virus from a noninfectious hamster tumor and the production of pseudotype sarcoma viruses with various murine leukemia viruses. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1164–1169. doi: 10.1073/pnas.56.4.1164. [DOI] [PMC free article] [PubMed] [Google Scholar]
  12. MOLONEY J. B. Biological studies on a lymphoid-leukemia virus extracted from sarcoma 37. I. Origin and introductory investigations. J Natl Cancer Inst. 1960 Apr;24:933–951. [PubMed] [Google Scholar]
  13. Perk K., Viola M. V., Smith K. L., Wivel N. A., Moloney J. B. Biologic studies on hamster tumors induced by the murine sarcoma virus (Moloney). Cancer Res. 1969 May;29(5):1089–1102. [PubMed] [Google Scholar]
  14. RUBIN H. An analysis of the assay of Rous sarcoma cells in vitro by the infective center technique. Virology. 1960 Jan;10:29–49. doi: 10.1016/0042-6822(60)90004-0. [DOI] [PubMed] [Google Scholar]
  15. Stenback W. A., Van Hoosier G. L., Jr, Trentin J. J. Virus particles in hamster tumors as revealed by electron microscopy. Proc Soc Exp Biol Med. 1966 Aug-Sep;122(4):1219–1223. doi: 10.3181/00379727-122-31365. [DOI] [PubMed] [Google Scholar]
  16. Ting R. C. Biological and serological properties of viral particles from a nonproducer rat neoplasm induced by murine sarcoma virus (Moloney). J Virol. 1968 Sep;2(9):865–868. doi: 10.1128/jvi.2.9.865-868.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Vogt P. K. A virus released by "nonproducing" Rous sarcoma cells. Proc Natl Acad Sci U S A. 1967 Sep;58(3):801–808. doi: 10.1073/pnas.58.3.801. [DOI] [PMC free article] [PubMed] [Google Scholar]

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