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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Mar;65(3):633–637. doi: 10.1073/pnas.65.3.633

Stability of a Position-Effect Variegation in Normal and Transdetermined Larval Blastemas from Drosophila melanogaster

Ernst Hadorn 1,2, Robert Gsell 1,2, Jack Schultz 1,2,*
PMCID: PMC282953  PMID: 5267143

Abstract

Male genital disks of a yellow-variegated genotype were implanted into the abdomens of adult females to test the stability of variegated clones in the blastemas formed by the implants. Upon reimplantation into metamorphosing larval hosts, test fragments of the proliferating blastemas differentiated into variegated organs, with yellow and wild-type areas. In later transfer generations clones were separated, which appeared stable for either wild type or yellow; variegation was no longer occurring. In all the lines differentiation occurred also into other organs (allotypic) than those characteristically formed by the genital disc (transdetermination). The absence of new variegation in these transdetermined organs is discussed as evidence against a reversal to the embryonic state in the cells of the transdetermining blastema. The variegation process seems not to be affected by, nor does it in this case influence, the process of transdetermination.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Baker W. K. Position-effect variegation. Adv Genet. 1968;14:133–169. [PubMed] [Google Scholar]
  2. García-Bellido A. Pattern reconstruction by dissociated imaginal disk cells of Drosophila melanogaster. Dev Biol. 1966 Oct;14(2):278–306. doi: 10.1016/0012-1606(66)90017-0. [DOI] [PubMed] [Google Scholar]
  3. Gehring W. Clonal analysis of determination dynamics in cultures of imaginal disks in Drosophila melanogaster. Dev Biol. 1967 Nov;16(5):438–456. doi: 10.1016/0012-1606(67)90058-9. [DOI] [PubMed] [Google Scholar]
  4. Hadorn E., Hürlimann R., Mindek G., Schubiger G., Staub M. Entwicklungsleistungen embryonaler Blasteme von Drosophila nach Kultur im Adultwirt. Rev Suisse Zool. 1968 Sep;75(3):557–569. [PubMed] [Google Scholar]
  5. Hadorn E. Konstanz, Wechsel und Typus der Determination und Differenzierung in Zellen aus männlichen Genitalanlagen von Drosophila melanogaster nach Dauerkultur in vivo. Dev Biol. 1966 Jun;13(3):424–509. doi: 10.1016/0012-1606(66)90058-3. [DOI] [PubMed] [Google Scholar]
  6. Schubiger G., Hadorn E. Auto- und allotypische Differenzierungen aus in vivo-kultivierten Vorderbeinblastemen von Drosophila melanogaster. Dev Biol. 1968 May;17(5):584–602. doi: 10.1016/0012-1606(68)90007-9. [DOI] [PubMed] [Google Scholar]
  7. Schultz J. Genes, differentiation, and animal development. Brookhaven Symp Biol. 1965;18:116–147. [PubMed] [Google Scholar]
  8. Tobler H. Zellspezifische Determination und Beziehung zwischen Proliferation und Transdetermination in Bein- und Flügelprimordien von Drosophila melanogaster. J Embryol Exp Morphol. 1966 Dec;16(3):609–633. [PubMed] [Google Scholar]

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