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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Mar;65(3):721–728. doi: 10.1073/pnas.65.3.721

On the Interactions of Lipids and Proteins in the Red Blood Cell Membrane*

Michael Glaser 1,2,3,, Henry Simpkins 1,2,3, S J Singer 1,2,3,, Michael Sheetz 1,2,3,, Sunney I Chan 1,2,3
PMCID: PMC282966  PMID: 5267150

Abstract

The effects of temperature and of the action of a purified phospholipase C enzyme preparation on human red blood cell membranes has been investigated by chemical analyses, circular dichroism, and proton magnetic resonance measurements. The results indicate that a substantial fraction of the phospholipids and the proteins of the membranes can change structure independently of one another, suggesting a mosaic pattern for the organization of the lipids and proteins in membranes.

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Selected References

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