Abstract
Either a subconvulsive or a high convulsive current was delivered transcranially at various intervals after a learning trial to independent groups of newly hatched chicks. The one-trial learning involves suppression of the chicks' predilection to peck at a small shiny bead. The effect of current on retention was measured one day later. Results indicate a current-sensitive memory consolidation period of about 30 seconds that cannot be appreciably prolonged by a tenfold increase in current intensity and a simultaneous twofold increase in current duration. On the other hand, at comparable trial-to-current intervals within this brief consolidation period, more retention deficit was caused by the higher current. Beyond this critical period, both currents still effected some retention deficit, but it did not seem to vary with the trial-to-current interval from one minute to 24 hours. Overt muscular convulsion was unnecessary for the retrograde amnesia effect. The subconvulsive current may be a more pure agent for consolidation studies because the high, convulsive current may affect test performance in ways other than disrupting the consolidation processes.
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Selected References
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- Alpern H. P., McGaugh J. L. Retrograde amnesia as a function of duration of electroshock stimulation. J Comp Physiol Psychol. 1968 Apr;65(2):265–269. doi: 10.1037/h0025536. [DOI] [PubMed] [Google Scholar]
- Bovet D., Bovet-Nitti F., Oliverio A. Genetic aspects of learning and memory in mice. Science. 1969 Jan 10;163(3863):139–149. doi: 10.1126/science.163.3863.139. [DOI] [PubMed] [Google Scholar]
- Lee-Teng E., Giaquinto S. Electrocorticograms following threshold transcranial electroshock for retrograde amnesia in chicks. Exp Neurol. 1969 Apr;23(4):485–490. doi: 10.1016/0014-4886(69)90117-4. [DOI] [PubMed] [Google Scholar]
- Lee-Teng E. Retrograde amnesia in relation to subconvulsive and convulsive currents in chicks. J Comp Physiol Psychol. 1969 Feb;67(2):135–139. doi: 10.1037/h0026791. [DOI] [PubMed] [Google Scholar]
- Lee-Teng E., Sherman S. M. Memory consolidation of one-trial learning in chicks. Proc Natl Acad Sci U S A. 1966 Sep;56(3):926–931. doi: 10.1073/pnas.56.3.926. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Miller A. J. Variations in retrograde amnesia with parameters of electroconvulsive shock and time of testing. J Comp Physiol Psychol. 1968 Aug;66(1):40–47. doi: 10.1037/h0025965. [DOI] [PubMed] [Google Scholar]
- Misanin J. R., Miller R. R., Lewis D. J. Retrograde amnesia produced by electroconvulsive shock after reactivation of a consolidated memory trace. Science. 1968 May 3;160(3827):554–555. doi: 10.1126/science.160.3827.554. [DOI] [PubMed] [Google Scholar]
- Pryor G. T., Otis L. S., Scott M. K., Colwell J. J. Duration of chronic electroshock treatment in relation to brain weight, brain chemistry, and behavior. J Comp Physiol Psychol. 1967 Apr;63(2):236–239. doi: 10.1037/h0024354. [DOI] [PubMed] [Google Scholar]
- ROUTTENBERG A., KAY K. E. EFFECT OF ONE ELECTROCONVULSIVE SEIZURE ON RAT BEHAVIOR. J Comp Physiol Psychol. 1965 Apr;59:285–288. doi: 10.1037/h0021819. [DOI] [PubMed] [Google Scholar]
- Riddell W. I. Effect of electroconvulsive shock: permanent or temporary retrograde amnesia. J Comp Physiol Psychol. 1969 Feb;67(2):140–144. doi: 10.1037/h0026794. [DOI] [PubMed] [Google Scholar]
- Schneider A. M., Sherman W. Amnesia: a function of the temporal relation of footshock to electroconvulsive shock. Science. 1968 Jan 12;159(3811):219–221. doi: 10.1126/science.159.3811.219. [DOI] [PubMed] [Google Scholar]
- Zinkin S., Miller A. J. Recovery of memory after amnesia induced by electroconvulsive shock. Science. 1967 Jan 6;155(3758):102–104. doi: 10.1126/science.155.3758.102. [DOI] [PubMed] [Google Scholar]