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. 1970 Jun;66(2):329–336. doi: 10.1073/pnas.66.2.329

DNA Complementary to Viral RNA in Leukemic Cells Induced by Avian Myeloblastosis Virus*

M A Baluda 1,, D P Nayak 1,
PMCID: PMC283048  PMID: 4317913

Abstract

Nucleic acid hybridization studies were made between 71S-AMV-RNA and DNA from leukemic myeloblasts and from normal chicken cells. There was homology between the viral RNA and chicken cell DNA and to a greater extent between viral RNA and leukemic cell DNA. Leukemic cell DNA hybridized approximately twice as much viral RNA as did normal chicken DNA. Thermal melting studies showed that the viral RNA bound to normal and leukemic cell DNA consists of long polynucleotides (Tm = 87° and 92°C, respectively, in 2× saline citrate). This suggests that the leukemic cells contain a DNA template of the viral RNA.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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