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. 1970 Sep;67(1):52–58. doi: 10.1073/pnas.67.1.52

Low Temperature and Chloramphenicol Induction of Respiratory Deficiency in a Cold-Sensitive Mutant of Saccharomyces cerevisiae*

Paul O Weislogel 1,†, Ronald A Butow 1
PMCID: PMC283165  PMID: 5272328

Abstract

A cold-sensitive mutant of a haploid strain of Saccharomyces cerevisiae has been isolated by selection for impaired growth at 18° on nonfermentable carbon sources. Growth of the mutant on glucose or galactose at either 28 or 18° is similar to that of the parental strain. The cold-sensitive strain is highly mutable to a cytoplasmic petite when grown at 18°, or when grown at 28° in the presence of 4 mg/ml of chloramphenicol. Cold sensitivity is not observed in the conversion of promitochondria to mitochondria. We conclude that mitochondrial protein synthesis is required for maintaining the stability of the mitochondrial genome.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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