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. 1970 Sep;67(1):148–155. doi: 10.1073/pnas.67.1.148

Identification of Proinsulin and C-Peptide in Human Serum by a Specific Immunoassay*

Franco Melani 1,2,†, Arthur H Rubenstein 1,2, Philip E Oyer 1,2,‡, Donald F Steiner 1,2,§
PMCID: PMC283181  PMID: 4318774

Abstract

An immunoassay for the measurement of human proinsulin and C-peptide is described. By a combination of this system and an insulin immunoassay, proinsulin, insulin, and C-peptide were identified in acid-ethanol extracts of serum after gel filtration. In keeping with the results of biosynthetic studies, insulin and C-peptide were found to be present in equimolar amounts. The absolute values of serum proinsulin determined independently in the two assays corresponded closely.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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