Skip to main content
NCBI home page
Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Sep;67(1):180–184. doi: 10.1073/pnas.67.1.180

Role of Adrenal Cortical Function in Toxicity of Polyriboinosinic·Polyribocytidylic Acid and Its Component Homopolymers

Morris S Zedeck 1,2, Hans Marquardt 1,2, Stephen S Sternberg 1,2, Martin Fleisher 1,2, L D Hamilton 1,2
PMCID: PMC283185  PMID: 5272311

Abstract

Adrenalectomized rats are 1000 times more sensitive to lethal effects of the double-stranded complex polyriboinosinic·polyribocytidylic acid than intact rats. They are protected from such lethal effects by corticosterone. The complex can rapidly induce diffuse, severe necrosis of villous epithelium in small intestine without damage in crypts. Injection of the individual homopolymers, polyriboinosinic acid and polyribocytidylic acid, separately but in rapid succession is at least as lethal as injection of the complex.

Full text

PDF
180

Images in this article

182Image
on p.182
182Image
on p.182

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. ENGEL M. G., ENGEL F. L. Fasting ketosis in the adrenalectomized and cortisone-treated rat. Endocrinology. 1954 Nov;55(5):593–600. doi: 10.1210/endo-55-5-593. [DOI] [PubMed] [Google Scholar]
  2. Field A. K., Tytell A. A., Lampson G. P., Hilleman M. R. Inducers of interferon and host resistance. II. Multistranded synthetic polynucleotide complexes. Proc Natl Acad Sci U S A. 1967 Sep;58(3):1004–1010. doi: 10.1073/pnas.58.3.1004. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Hamilton L. D., Babcock V. I., Southam C. M. Inhibition of herpes simplex virus by synthetic double-stranded RNA (polyriboadenylic and polyribouridylic acids and polyriboinosinic and polyribocytidylic acids). Proc Natl Acad Sci U S A. 1969 Nov;64(3):878–883. doi: 10.1073/pnas.64.3.878. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Levy H. B., Law L. W., Rabson A. S. Inhibition of tumor growth by polyinosinic-polycytidylic acid. Proc Natl Acad Sci U S A. 1969 Feb;62(2):357–361. doi: 10.1073/pnas.62.2.357. [DOI] [PMC free article] [PubMed] [Google Scholar]
  5. STOCK C. C., SUGIURA K. Screening steroids against a spectrum of tumors. Ann N Y Acad Sci. 1958 Dec 5;76(3):720–728. [PubMed] [Google Scholar]
  6. Schell P. L. Uptake of polynucleotides by intact mammalian cells (IV): synthetic homoribopolynucleotides. Z Naturforsch B. 1968 Aug;23(8):1117–1119. doi: 10.1515/znb-1968-0825. [DOI] [PubMed] [Google Scholar]
  7. Zedeck M. S., Sternberg S. S., Poynter R. W., McGowan J. Biochemical and pathological effects of methylazoxymethanol acetate, a potent carcinogen. Cancer Res. 1970 Mar;30(3):801–812. [PubMed] [Google Scholar]

Articles from Proceedings of the National Academy of Sciences of the United States of America are provided here courtesy of National Academy of Sciences

RESOURCES