Phosphorylation of MNAR Promotes Estrogen Activation of Phosphatidylinositol 3-Kinase

Volume 27, no. 5, p. 1904-1913, 2007. The publisher hereby retracts this article. Although the data showing an estrogen-dependent ternary complex of MNAR, estrogen receptor alpha (ERα), and the p85 subunit of phosphatidylinositol 3-kinase (PI3K) and the requirement for the activation of c-Src and ERα for the MNAR-p85 interaction are accurate, Wyeth Research has determined that the data demonstrating the phosphorylation of the Y920 residue of MNAR by c-Src and the requirement of Y920 phosphorylation of MNAR for estrogen-mediated activation of PI3K are unreliable.