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. 1970 Oct;67(2):717–723. doi: 10.1073/pnas.67.2.717

Symmetric Replication of the Bacillus subtilis Chromosome*

William G Quinn 1, Noboru Sueoka 1
PMCID: PMC283264  PMID: 5002094

Abstract

Synchronously replicating chromosomes in germinating spores of Bacillus subtilis were labeled near the origin with [3H]bromouracil. The label appeared in heavy-light DNA. When cell growth and chromosome replication were continued in unlabeled bromouracil, nearly all the tritium label was transferred to heavy-heavy DNA while the terminus remained unreplicated. This implies that both origins of the replicating chromosome can undergo reinitiation. Therefore, during multifork replication the chromosome takes on the symmetric „dichotomous” form rather than the asymmetric configuration predicted by the rolling circle model.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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