Figure 2.

Expression of CD38 on virally infected CLL cells. A dose dependent increase in CD38 expression was observed in both the number of cells expressing CD38 (A) and in the MFI (B) of samples following treatment with CD38 virus (diamonds). No such increase is observed following the addition of a comparable amount of GFP virus (squares). Following transduction a high level of CD38 expression was observed on the surface of CLL cells following 24 h incubation. This level was sustained over a period of five days as measured by the percentage of cells expressing the CD38 antigen (C) and by the MFI (D) of the sample.