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Proceedings of the National Academy of Sciences of the United States of America logoLink to Proceedings of the National Academy of Sciences of the United States of America
. 1970 Nov;67(3):1101–1108. doi: 10.1073/pnas.67.3.1101

Temperature-Sensitive Mutations in Drosophila melanogaster, V. A Mutation Affecting Concentrations of Pteridines*

Thomas Grigliatti 1, David T Suzuki 1
PMCID: PMC283323  PMID: 5274440

Abstract

A temperature-sensitive ras allele has an effective lethal phase at 29°C about 12 hr after pupation and a temperature-sensitive period for lethality beginning midway through the third larval instar and ending around pupation. The mutation also alters the quantity of pteridines present in the eyes, testes, and Malpighian tubules at 29°C. The temperature-sensitive period for pigment production in the Malpighian tubules occurs in the egg and first instar larvae, and in eyes and testes after pupation. The demonstrated autonomy of the mutant in the eyes implies the tissue-specific functioning of the gene. We suggest that the different temperature-sensitive periods for a single mutation indicate tissue-specific activation of a gene at different times during development, although the possibility of activation of preformed polypeptides has not been eliminated.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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