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. 1970 Nov;67(3):1192–1199. doi: 10.1073/pnas.67.3.1192

A Genetic Marker in the Variable Region of Light Chains of Mouse Immunoglobulins*

Gerald M Edelman 1, Paul D Gottlieb 1
PMCID: PMC283336  PMID: 5274448

Abstract

A genetic variation was observed upon autoradiographic comparison of tryptic peptide maps of 14C-labeled normal light chains from 17 different inbred strains of mice. The difference was found in strains AKR/J, C58/J, and RF/J. Chemical analyses showed that the differences were in a region of the amino acid sequence in the neighborhood of half-cystine I of the variable region of the light chain. Breeding experiments showed that the difference segregated in a classical Mendelian fashion.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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