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. 1970 Nov;67(3):1241–1247. doi: 10.1073/pnas.67.3.1241

Use of a Snake Venom Toxin to Characterize the Cholinergic Receptor Protein*

Jean-Pierre Changeux †, Michiki Kasai †, Chen-Yuan Lee ‡
PMCID: PMC283343  PMID: 5274453

Abstract

α-Bungarotoxin, a polypeptide of mol wt 8000 purified from the venom of Bungarus multicinctus, blocks irreversibly and specifically the excitation by cholinergic agonists on the isolated electroplax and on purified membrane fragments in vitro. The toxin also blocks the in vitro binding of decamethonium to a protein recently isolated from electric tissue. This observation strengthens our earlier conclusion that this protein is the cholinergic receptor macromolecule.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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