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. 1970 Nov;67(3):1521–1527. doi: 10.1073/pnas.67.3.1521

Effect of Muscle Denervation on Growth of Transplanted Tumor in Mice*

Stanley Batkin 1,2, Lawrence H Piette 1,2, Ellen Wildman 1,2
PMCID: PMC283385  PMID: 5274476

Abstract

A temporary retardation of transplanted Round Cell Neuroblastoma growth in the gastrocnemius muscle of mice was observed in 20% of the animals after denervation of the muscle. The tumor cells in these denervated animals showed structural alterations and deterioration in function. These altered cells when mixed with associated denervated muscle tissue, to which was added fresh tumor, produced a higher percentage of retardation upon subsequent transplants in innervated muscle.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Engel W. K., Karpati G. Impaired skeletal muscle maturation following neonatal neurectomy. Dev Biol. 1968 Jun;17(6):713–723. doi: 10.1016/0012-1606(68)90015-8. [DOI] [PubMed] [Google Scholar]
  2. FURTH J. Influence of host factors on the growth of neoplastic cells. Cancer Res. 1963 Jan;23:21–34. [PubMed] [Google Scholar]
  3. Forman C. E. Preliminary studies in animals concerning the relationship between the nervous system and cancer. Ann N Y Acad Sci. 1966 Jan 21;125(3):952–958. doi: 10.1111/j.1749-6632.1966.tb45447.x. [DOI] [PubMed] [Google Scholar]
  4. GOLDSTEIN M. N., BURDMAN J. A., JOURNEY L. J. LONG-TERM TISSUE CULTURE OF NEUROBLASTOMAS. II. MORPHOLOGIC EVIDENCE FOR DIFFERENTIATION AND MATURATION. J Natl Cancer Inst. 1964 Jan;32:165–199. [PubMed] [Google Scholar]
  5. HOGENHUIS L. A., ENGEL W. K. HISTOCHEMISTRY AND CYTOCHEMISTRY OF EXPERIMENTALLY DENERVATED GUINEA PIG MUSCLE. I. HISTOCHEMISTRY. Acta Anat (Basel) 1965;60:39–65. doi: 10.1159/000142635. [DOI] [PubMed] [Google Scholar]
  6. HULS H. N., LEONARD S. L. Phosphorylase activity in denervated skeletal muscle. Proc Soc Exp Biol Med. 1961 Oct;108:224–228. doi: 10.3181/00379727-108-26898. [DOI] [PubMed] [Google Scholar]
  7. Kavetsky R. E., Turkevich N. M., Balitsky K. P. On the psychophysiological mechanism of the organism's resistance to tumor growth. Ann N Y Acad Sci. 1966 Jan 21;125(3):933–945. doi: 10.1111/j.1749-6632.1966.tb45445.x. [DOI] [PubMed] [Google Scholar]
  8. LESHAN L. Psychological states as factors in the development of malignant disease: a critical review. J Natl Cancer Inst. 1959 Jan;22(1):1–18. [PubMed] [Google Scholar]
  9. Laird A. K. Dynamics of growth in tumors and in normal organisms. Natl Cancer Inst Monogr. 1969 May;30:15–28. [PubMed] [Google Scholar]
  10. SCHARRER B. Gastric cancer experimentally induced in insects by nerve severance. J Natl Cancer Inst. 1949 Oct;10(2):375; Disc, 399-403. [PubMed] [Google Scholar]
  11. Varon S. Possible involvement of nerve growth factors in neuroblastoma pathology. J Pediatr Surg. 1968 Feb;3(1):165–166. doi: 10.1016/0022-3468(68)91006-3. [DOI] [PubMed] [Google Scholar]

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