Abstract
Bovine parathyroid hormone has been isolated in homogeneous form, and its complete amino acid sequence determined. The bovine hormone is a single chain, 84 amino acids long. It contains amino-terminal alanine, and carboxyl-terminal glutamine. The bovine parathyroid hormone is approximately three times the length of the newly discovered hormone, thyrocalcitonin, whose action is reciprocal to parathyroid hormone.
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- AURBACH G. D. Isolation of parathyroid hormone after extraction with phenol. J Biol Chem. 1959 Dec;234:3179–3181. [PubMed] [Google Scholar]
- Arnaud C. D., Jr, Tenenhouse A. M., Rasmussen H. Parathyroid hormone. Annu Rev Physiol. 1967;29:349–372. doi: 10.1146/annurev.ph.29.030167.002025. [DOI] [PubMed] [Google Scholar]
- Behrens O. K., Grinnan E. L. Polypeptide hormones. Annu Rev Biochem. 1969;38:83–112. doi: 10.1146/annurev.bi.38.070169.000503. [DOI] [PubMed] [Google Scholar]
- Berson S. A., Yalow R. S., Aurbach G. D., Potts J. T. IMMUNOASSAY OF BOVINE AND HUMAN PARATHYROID HORMONE. Proc Natl Acad Sci U S A. 1963 May;49(5):613–617. doi: 10.1073/pnas.49.5.613. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Blombäck B., Blombäck M., Edman P., Hessel B. Human fibrinopeptides. Isolation, characterization and structure. Biochim Biophys Acta. 1966 Feb 28;115(2):371–396. doi: 10.1016/0304-4165(66)90437-5. [DOI] [PubMed] [Google Scholar]
- Brewer H. B., Jr, Keutmann H. T., Potts J. T., Jr, Reisfeld R. A., Schlueter R., Munson P. L. Isolation and chemical properties of porcine thyrocalcitonin. J Biol Chem. 1968 Nov 10;243(21):5739–5747. [PubMed] [Google Scholar]
- Brewer H. B., Jr, Ronan R. Amino acid sequence of bovine thyrocalcitonin. Proc Natl Acad Sci U S A. 1969 Jul;63(3):940–947. doi: 10.1073/pnas.63.3.940. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Chase L. R., Aurbach G. D. Renal adenyl cyclase: anatomically separate sites for parathyroid hormone and vasopressin. Science. 1968 Feb 2;159(3814):545–547. doi: 10.1126/science.159.3814.545. [DOI] [PubMed] [Google Scholar]
- Copp D. H., Cockcroft D. W., Kueh Y. Ultimobranchial origin of calcitonin. Hypocalcemic effect of extracts from chicken glands. Can J Physiol Pharmacol. 1967 Nov;45(6):1095–1099. doi: 10.1139/y67-127. [DOI] [PubMed] [Google Scholar]
- Edman P., Begg G. A protein sequenator. Eur J Biochem. 1967 Mar;1(1):80–91. doi: 10.1007/978-3-662-25813-2_14. [DOI] [PubMed] [Google Scholar]
- Hirsch P. F., Munson P. L. Thyrocalcitonin. Physiol Rev. 1969 Jul;49(3):548–622. doi: 10.1152/physrev.1969.49.3.548. [DOI] [PubMed] [Google Scholar]
- Hubbard R. W., Kremen D. M. Increased sensitivity of accelerated amino acid ion-exchange chromatography. Anal Biochem. 1965 Sep;12(3):593–602. doi: 10.1016/0003-2697(65)90227-7. [DOI] [PubMed] [Google Scholar]
- Hubbard R. W. Studies in accelerated amino acid analysis. Biochem Biophys Res Commun. 1965 Jun 9;19(6):679–685. doi: 10.1016/0006-291x(65)90310-4. [DOI] [PubMed] [Google Scholar]
- KAWANISHI Y., IWAI K., ANDO T. DETERMINATION OF C-TERMINAL ARGININE AND ASPARAGINE OF PROTEINS BY CATALYTIC HYDRAZINOLYSIS. J Biochem. 1964 Oct;56:314–324. doi: 10.1093/oxfordjournals.jbchem.a127995. [DOI] [PubMed] [Google Scholar]
- Lequin R. M., Schopman W., Hackeng W. H., Persoon H. P. Some aspects of the radioimmunochemical determination of parathyroid hormone. Acta Physiol Pharmacol Neerl. 1967 Dec;14(4):519–519. [PubMed] [Google Scholar]
- MUNSON P. L. Studies on the role of the parathyroids in calcium and phosphorus metabolism. Ann N Y Acad Sci. 1955 Apr 27;60(5):776–796. doi: 10.1111/j.1749-6632.1955.tb40064.x. [DOI] [PubMed] [Google Scholar]
- Pisano J. J., Bronzert T. J. Analysis of amino acid phenylthiohydantoins by gas chromatography. J Biol Chem. 1969 Oct 25;244(20):5597–5607. [PubMed] [Google Scholar]
- Potts J. T., Jr, Aurbach G. D., Sherwood L. M. Parathyroid hormone: chemical properties and structural requirements for biological and immunological activity. Recent Prog Horm Res. 1966;22:101–151. doi: 10.1016/b978-1-4831-9825-5.50006-3. [DOI] [PubMed] [Google Scholar]
- Reis E., Canterbury J. M. A radioimmunoassay for parathyroid hormone in man. Proc Soc Exp Biol Med. 1968 Jun;128(2):501–504. doi: 10.3181/00379727-128-33050. [DOI] [PubMed] [Google Scholar]
- Tashjian A. H., Jr, Frantz A. G., Lee J. B. Pseudohypoparathyroidism: assays of parathyroid hormone and thyrocalcitonin. Proc Natl Acad Sci U S A. 1966 Oct;56(4):1138–1142. doi: 10.1073/pnas.56.4.1138. [DOI] [PMC free article] [PubMed] [Google Scholar]

