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. 1970 Dec;67(4):1886–1893. doi: 10.1073/pnas.67.4.1886

The SV40 Pseudovirus: Its Potential for General Transduction in Animal Cells

Leo Grady 1, David Axelrod 1, David Trilling 1
PMCID: PMC283443  PMID: 4321350

Abstract

The rates of reassociation of DNA from a monkey cell line (Vero), from SV40 pseudovirus (consisting of Vero DNA and virus protein coat), and from mature SV40 were measured. The results show that the host DNA in the pseudovirus contains repeated and unique sequences in the same proportions as normal host DNA; hence, no one portion of the host genome is preferentially incorporated in the pseudovirus. It was also shown that the Vero DNA in the pseudoviruses enters the nuclei of mouse embryo cells without loss of its physical integrity.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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