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. 1970 Dec;67(4):1901–1908. doi: 10.1073/pnas.67.4.1901

Possible Role of Microtubules in Thyroid Secretion

John A Williams 1, J Wolff 1
PMCID: PMC283445  PMID: 4321351

Abstract

Colchicine and other microtubule-active agents have been found to block the release, stimulated by either thyroid-stimulating hormone or by dibutyryl cyclic adenosine 3′:5′-monophosphate, of 131I from previously 131I-labeled mouse thyroid glands in vitro. The time and concentration characteristics of these inhibitors are consistent with their actions on microtubules in other systems. [3H]colchicine was also shown to be bound to a soluble 6S protein of bovine thyroid slices similar to the protein identified in other systems as a microtubular subunit. The demonstrated inhibition of colloid droplet formation and absence of an effect on thyroidal adenyl cyclase or cyclic 3′:5′-phosphodiesterase suggests a colchicine-sensitive role for microtubules in colloid endocytosis in the thyroid gland.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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