Table 2.

DSC transition midpoint temperatures at different scan rates and transition activation energies at pH 6 and pH 7.5.

(Tm in °C)	pH 6			pH 7.5
Scanrate (°C/h)	Tm1	Tm2	Tm3	Tm1	Tm2	Tm3
15	48.8	81.2	100.2	52.7	79.6	91.6
30	50.5	82.2	100.5	54.2	81.1	93.8
60	52.6	84.9	-	55.8	83.0	95.5
90	54	85.9	-	57.1	84.3	-
Ea**	297±13	391±14	-*	361±19	391±20	422±18
kJ/mol

^*a third transition is not detected the higher scan rates at pH 6, precluding estimation of the activation energy

^**standard errors from fitting

dH<dHv for transition 3 → aggregation. Aggregation kinetics faster at pH 6 than pH 7.5 as Tm is less scan rate dependent at pH 6 compared to pH 7.5 (see Supplementary table 2).