Abstract
Bragg, P. D. (University of British Columbia, Vancouver, B.C., Canada), and W. J. Polglase. Inhibition of oxidative phosphorylation in Escherichia coli by dihydrostreptomycin. J. Bacteriol. 86:1236–1240. 1963.—Dihydrostreptomycin inhibited the oxidation of succinate in extracts of antibiotic-sensitive Escherichia coli. The inhibitable reaction required both the particulate and the supernatant fractions from sonic extracts which had been centrifuged at 100,000 × g. Dihydrostreptomycin was found to inhibit phosphorylation coupled with the oxidation of reduced nicotinamide adenine dinucleotide (NADH). The inhibition of oxidative phosphorylation by dihydrostreptomycin appeared to precede the effect of the antibiotic on oxidation. The streptomycin antagonist, 2-heptyl-4-hydroxyquinoline N-oxide, inhibited the oxidation of succinate and of NADH, but showed little effect on oxidative phosphorylation. Oxidative phosphorylation was not affected by dihydrostreptomycin in strains of E. coli which were antibiotic-resistant or -dependent.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BRAGG P. D., POLGLASE W. J. ACTION OF DIHYDROSTREPTOMYCIN AND ANTAGONISM BY CATIONS. J Bacteriol. 1963 Mar;85:590–594. doi: 10.1128/jb.85.3.590-594.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BRAGG P. D., POLGLASE W. J. EFFECT OF DIHYDROSTREPTOMYCIN ON TETRAZOLIUM DYE REDUCTION IN ESCHERICHIA COLI. J Bacteriol. 1963 Apr;85:795–800. doi: 10.1128/jb.85.4.795-800.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BRAGG P. D., POLGLASE W. J. ELECTRON-TRANSPORT COMPONENTS OF STREPTOMYCIN-DEPENDENT ESCHERICHIA COLI. J Bacteriol. 1963 Sep;86:544–547. doi: 10.1128/jb.86.3.544-547.1963. [DOI] [PMC free article] [PubMed] [Google Scholar]
- BRAGG P. D., POLGLASE W. J. Extracellular metabolites of streptomycin mutants of Escherichia coli. J Bacteriol. 1962 Aug;84:370–374. doi: 10.1128/jb.84.2.370-374.1962. [DOI] [PMC free article] [PubMed] [Google Scholar]
- ENGELBERG H., ARTMAN M. Studies on streptomycin dependent bacteria: effect of growth in limiting amounts of streptomycin on respiration and fermentation of a streptomycin dependent mutant of Escherichia coli. Biochim Biophys Acta. 1961 Mar 4;47:553–560. doi: 10.1016/0006-3002(61)90550-9. [DOI] [PubMed] [Google Scholar]
- LIGHTBOWN J. W., JACKSON F. L. Inhibition of cytochrome systems of heart muscle and certain bacteria by the antagonists of dihydrostreptomycin: 2-alkyl-4-hydroxyquinoline N-oxides. Biochem J. 1956 May;63(1):130–137. doi: 10.1042/bj0630130. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LIGHTBOWN J. W. Metabolic processes underlying streptomycin resistance. G Ital Chemioter. 1957 Jan-Jun;4(1-2):22–32. [PubMed] [Google Scholar]
- PINCHOT G. B. A rapid method for measuring phosphorylation coupled to the oxidation of reduced diphosphopyridine nucleotide. J Biol Chem. 1957 Nov;229(1):11–23. [PubMed] [Google Scholar]
- PINCHOT G. B. Phosphorylation coupled to electron transport in cell-free extracts of Alcaligenes faecalis. J Biol Chem. 1953 Nov;205(1):65–74. [PubMed] [Google Scholar]