Skip to main content
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1980 Jan;17(1):80–83. doi: 10.1128/aac.17.1.80

Isolation of an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzae.

S M Markowitz
PMCID: PMC283729  PMID: 6965443

Abstract

A 79-year-old female developed endocarditis and meningitis due to an ampicillin-resistant, non-beta-lactamase-producing strain of Haemophilus influenzae. Carbenicillin and gentamicin therapy resulted in bacteriological and clinical cure. The mechanism of resistance of ampicillin-resistant, non-beta-lactamase-producing strains of H. influenzae is unknown.

Full text

PDF
80

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bryan C. S., Marney S. R., Jr, Alford R. H., Bryant R. E. Gram-negative bacillary endocarditis. Interpretation of the serum bactericial test. Am J Med. 1975 Feb;58(2):209–215. doi: 10.1016/0002-9343(75)90571-9. [DOI] [PubMed] [Google Scholar]
  2. Catlin B. W. Iodometric detection of Haemophilus influenzae beta-lactamase: rapid presumptive test for ampicillin resistance. Antimicrob Agents Chemother. 1975 Mar;7(3):265–270. doi: 10.1128/aac.7.3.265. [DOI] [PMC free article] [PubMed] [Google Scholar]
  3. Chunn C. J., Jones S. R., McCutchan J. A., Young E. J., Gilbert D. N. Haemophilus parainfluenzae infective endocarditis. Medicine (Baltimore) 1977 Mar;56(2):99–113. doi: 10.1097/00005792-197703000-00002. [DOI] [PubMed] [Google Scholar]
  4. Clewell D. B., Helinski D. R. Properties of a supercoiled deoxyribonucleic acid-protein relaxation complex and strand specificity of the relaxation event. Biochemistry. 1970 Oct 27;9(22):4428–4440. doi: 10.1021/bi00824a026. [DOI] [PubMed] [Google Scholar]
  5. Elwell L. P., De Graaff J., Seibert D., Falkow S. Plasmid-linked ampicillin resistance in haempohilus influenza type b. Infect Immun. 1975 Aug;12(2):404–410. doi: 10.1128/iai.12.2.404-410.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Ericsson H. M., Sherris J. C. Antibiotic sensitivity testing. Report of an international collaborative study. Acta Pathol Microbiol Scand B Microbiol Immunol. 1971;217(Suppl):1+–1+. [PubMed] [Google Scholar]
  7. Everett E. D., Rham A. E., Jr, Adaniya R., Stevens D. L., McNitt T. R. Haemophilus influenzae pneumonia in adults. JAMA. 1977 Jul 25;238(4):319–321. [PubMed] [Google Scholar]
  8. Gordon R. C., Thompson T. R., Stevens L. I., Carlson W. H. In vitro susceptibility of Haemophilus influenzae to eight antibiotics. Antimicrob Agents Chemother. 1974 Jul;6(1):114–115. doi: 10.1128/aac.6.1.114. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Heffron F., Sublett R., Hedges R. W., Jacob A., Falkow S. Origin of the TEM-beta-lactamase gene found on plasmids. J Bacteriol. 1975 Apr;122(1):250–256. doi: 10.1128/jb.122.1.250-256.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Jorgensen J. H., Alexander G. A. Comparative activities of selected beta-lactam antibiotics against Haemophilus influenzae. Antimicrob Agents Chemother. 1978 Feb;13(2):342–343. doi: 10.1128/aac.13.2.342. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Khan W., Ross S., Rodriguez W., Controni G., Saz A. K. Haemophilus influenzae type B resistant to ampicillin. A report of two cases. JAMA. 1974 Jul 15;229(3):298–301. [PubMed] [Google Scholar]
  12. McGowan J. E., Jr, Klein J. O., Bratton L., Barnes M. W., Finland M. Meningitis and bacteremia due to Haemophilus influenzae: occurrence and mortality at Boston City Hospital in 12 selected years, 1935-1972. J Infect Dis. 1974 Aug;130(2):119–124. doi: 10.1093/infdis/130.2.119. [DOI] [PubMed] [Google Scholar]
  13. McGowan J. E., Jr, Terry P. M., Nahmias A. J. Susceptibility of Haemophilus influenzae isolates from blood and cerebrospinal fluid to ampicillin, chloramphenicol, and trimethoprim-sulfamethoxazole. Antimicrob Agents Chemother. 1976 Jan;9(1):137–139. doi: 10.1128/aac.9.1.137. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Medeiros A. A., O'Brien T. F. Ampicillin-resistant Haemophilus influenzae type B possessing a TEM-type beta-lactamase but little permeability barrier to ampicillin. Lancet. 1975 Mar 29;1(7909):716–719. doi: 10.1016/s0140-6736(75)91630-x. [DOI] [PubMed] [Google Scholar]
  15. Meyers J. A., Sanchez D., Elwell L. P., Falkow S. Simple agarose gel electrophoretic method for the identification and characterization of plasmid deoxyribonucleic acid. J Bacteriol. 1976 Sep;127(3):1529–1537. doi: 10.1128/jb.127.3.1529-1537.1976. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Sykes R. B., Matthew M., O'Callaghan C. H. R-factor mediated beta-lactamase production by Haemophilus influenzae. J Med Microbiol. 1975 Aug;8(3):437–441. doi: 10.1099/00222615-8-3-437. [DOI] [PubMed] [Google Scholar]
  18. Thornsberry C., Baker C. N., Kirven L. A., Swenson J. M. Susceptibility of ampicillin-resistant Haemophilus influenzae to seven penicillins. Antimicrob Agents Chemother. 1976 Jan;9(1):70–73. doi: 10.1128/aac.9.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  19. Thornsberry C., Kirven L. A. Ampicillin resistance in Haemophilus influenzae as determined by a rapid test for beta-lactamase production. Antimicrob Agents Chemother. 1974 Nov;6(5):653–654. doi: 10.1128/aac.6.5.653. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Thornsberry C., Kirven L. A. Antimicrobial susceptibility of Haemophilus influenzae. Antimicrob Agents Chemother. 1974 Nov;6(5):620–624. doi: 10.1128/aac.6.5.620. [DOI] [PMC free article] [PubMed] [Google Scholar]
  21. Ward J. I., Tsai T. F., Filice G. A., Fraser D. W. Prevalence of ampicillin- and chloramphenicol-resistant strains of Haemophilus influenzae causing meningitis and bacteremia: national survey of hospital laboratories. J Infect Dis. 1978 Sep;138(3):421–424. doi: 10.1093/infdis/138.3.421. [DOI] [PubMed] [Google Scholar]
  22. Ware S. J., McLaughlin S. Haemophilus meningitis in Portsmouth. Lancet. 1978 Jul 22;2(8082):197–199. doi: 10.1016/s0140-6736(78)91933-5. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES