Abstract
The concentration of spectinomycin in serum and cerebrospinal fluid was compared in rabbits with and without experimental pneumococcal meningitis. When injected intravenously, spectinomycin could not be detected in the cerebrospinal fluid of normal rabbits. In rabbits with meningeal inflammation, however, spectinomycin penetrated the blood-brain barrier and produced significant cerebrospinal fluid concentrations, equal to or well above spectinomycin minimal inhibitory concentrations for many bacterial species.
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Selected References
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- Bennett J. V., Brodie J. L., Benner E. J., Kirby W. M. Simplified, accurate method for antibiotic assay of clinical specimens. Appl Microbiol. 1966 Mar;14(2):170–177. doi: 10.1128/am.14.2.170-177.1966. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Brogden R. N., Avery G. S. New antibiotics: epicillin, minocycline and spectinomycin a summary of their antibacterial activity, pharmacokinetic properties and therapeutic efficacy. Drugs. 1972;3(5):314–330. doi: 10.2165/00003495-197203050-00002. [DOI] [PubMed] [Google Scholar]
- Eichenwald H. F. Some observations on dosage and toxicity of kanamycin in premature and full-term infants. Ann N Y Acad Sci. 1966 Jun 14;132(2):984–991. doi: 10.1111/j.1749-6632.1966.tb43021.x. [DOI] [PubMed] [Google Scholar]
- Finland M., Garner C., Wilcox C., Sabath L. D. Susceptibility of pneumococci and Haemophilus influenzae to antibacterial agents. Antimicrob Agents Chemother. 1976 Feb;9(2):274–287. doi: 10.1128/aac.9.2.274. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McCormack W. M., Finland M. Drugs five years later. Spectinomycin. Ann Intern Med. 1976 Jun;84(6):712–716. doi: 10.7326/0003-4819-84-6-712. [DOI] [PubMed] [Google Scholar]
- Wagner J. G., Novak E., Leslie L. G., Metzler C. M. Absorption, distribution, and elimination of spectinomycin dihydrochloride in man. Int Z Klin Pharmakol Ther Toxikol. 1968 Apr;1(4):261–285. [PubMed] [Google Scholar]
- Washington JA I. I., Yu P. K. In vitro antibacterial activity of spectinomycin. Antimicrob Agents Chemother. 1972 Dec;2(6):427–430. doi: 10.1128/aac.2.6.427. [DOI] [PMC free article] [PubMed] [Google Scholar]