Abstract
At various times before surgery, 33 patients undergoing coronary artery bypass or cardiac valve replacement surgery received a single 2.0-g dose of either cefazolin or cephradine. Simultaneous single serum, atrial appendage, and pericardial fluid samples were obtained from the patients at various times and analyzed for drug content. Compared with cephradine, cefazolin yielded higher total serum, atrial appendage, and pericardial fluid levels. Unbound (free) levels of cephradine in serum and pericardial fluid were, however, higher than those of cefazolin. It remains uncertain whether the higher and more prolonged total levels of cefazolin in the right atrial appendage and in serum, or the higher free levels of cephradine in pericardial fluid and in serum, provide either one with a therapeutic advantage.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Amoury R. A., Bowman F. O., Jr, Malm J. R. Endocarditis associated with intracardiac prostheses. Diagnosis, management, and prophylaxis. J Thorac Cardiovasc Surg. 1966 Jan;51(1):36–48. [PubMed] [Google Scholar]
- Bassaris H. P., Quintiliani R., Maderazo E. G., Tilton R. C., Nightingale C. H. Pharmacokinetics and penetration characteristics of cefazolin into human spinal fluid. Curr Ther Res Clin Exp. 1976 Jan;19(1):110–120. [PubMed] [Google Scholar]
- Burke J. F. The effective period of preventive antibiotic action in experimental incisions and dermal lesions. Surgery. 1961 Jul;50:161–168. [PubMed] [Google Scholar]
- Greene D. S., Quintiliani R., Nightingale C. H. Binding rate of antibacterials to serum proteins. J Pharm Sci. 1977 Nov;66(11):1663–1664. doi: 10.1002/jps.2600661150. [DOI] [PubMed] [Google Scholar]
- Nightingale C. H., Greene D. S., Quintiliani R. Pharmacokinetics and clinical use of cephalosporin antibiotics. J Pharm Sci. 1975 Dec;64(12):1899–1926. doi: 10.1002/jps.2600641202. [DOI] [PubMed] [Google Scholar]
- Quintiliani R., Klimek J., Nightingale C. H. Penetration of cephapirin and cephalothin into the right atrial appendage and pericardial fluid of patients undergoing open-heart surgery. J Infect Dis. 1979 Mar;139(3):348–352. doi: 10.1093/infdis/139.3.348. [DOI] [PubMed] [Google Scholar]
- Reed W. A. Antibiotics and cardiac surgery. J Thorac Cardiovasc Surg. 1965 Dec;50(6):888–892. [PubMed] [Google Scholar]