Abstract
The pharmacokinetics of nafcillin were studied in 13 premature neonates with suspected sepsis. The mean weight of the infants studied was 1.19 kg (range, 0.73 to 2.21 kg). Infants less than 7 days of age were given 100 mg of nafcillin per kg per 24 h (every 12 h), and infants more than 7 days of age were given 100 mg of nafcillin per kg per 24 h (every 8 h). Blood samples were obtained before the first dose on day 3 of therapy and at 0.5, 1.5, 3, and 6 h thereafter. Nafcillin concentrations were measured by a microbiological assay. A mean volume of distribution of 326 ml/kg and an elimination rate constant of 0.2040 h-1 were obtained in 10 patients less than 21 days of age. Three patients from 24 to 68 days of age had a mean volume of distribution of 303 ml/min and a mean elimination rate constant of 0.3944 h-1 (P less than 0.05). These data suggest that doses of nafcillin lower than those currently recommended may be adequate to achieve desired peak plasma levels of approximately 75 microgram/ml in infants with low birth weights.
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- Appel G. B., Neu H. C. The nephrotoxicity of antimicrobial agents (first of three parts). N Engl J Med. 1977 Mar 24;296(12):663–670. doi: 10.1056/NEJM197703242961205. [DOI] [PubMed] [Google Scholar]
- Aranda J. V., MacLeod S. M., Renton K. W., Eade N. R. Hepatic microsomal drug oxidation and electron transport in newborn infants. J Pediatr. 1974 Oct;85(4):534–542. doi: 10.1016/s0022-3476(74)80465-8. [DOI] [PubMed] [Google Scholar]
- Dubowitz L. M., Dubowitz V., Goldberg C. Clinical assessment of gestational age in the newborn infant. J Pediatr. 1970 Jul;77(1):1–10. doi: 10.1016/s0022-3476(70)80038-5. [DOI] [PubMed] [Google Scholar]
- Ervin F. R., Bullock W. E., Jr Simple assay for clindamycin in the presence of aminoglycosides. Antimicrob Agents Chemother. 1974 Dec;6(6):831–835. doi: 10.1128/aac.6.6.831. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Feldman W. E., Nelson J. D., Stanberry L. R. Clinical and pharmacokinetic evaluation of nafcillin in infants and children. J Pediatr. 1978 Dec;93(6):1029–1033. doi: 10.1016/s0022-3476(78)81251-7. [DOI] [PubMed] [Google Scholar]
- McCracken G. H., Jr, Eichenwald H. F. Antimicrobial therapy in infants and children. Part II. Therapy of infectious conditions. J Pediatr. 1978 Sep;93(3):357–377. doi: 10.1016/s0022-3476(78)81140-8. [DOI] [PubMed] [Google Scholar]
- Simon H. J., Yin E. J. Microbioassay of antimicrobial agents. Appl Microbiol. 1970 Apr;19(4):573–579. doi: 10.1128/am.19.4.573-579.1970. [DOI] [PMC free article] [PubMed] [Google Scholar]