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. 1980 Apr;17(4):757–761. doi: 10.1128/aac.17.4.757

In vitro antimicrobial activity of cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase-producing strains.

C N Baker, C Thornsberry, R N Jones
PMCID: PMC283867  PMID: 6249195

Abstract

Minimum inhibitory concentrations and agar disk diffusion tests were determined on clinical isolates of beta-lactamase-positive and beta-lactamase-negative Neisseria gonorrhoeae and Haemophilus influenzae with the newer beta-lactam antibiotics, cefoperazone, cefotaxime, moxalactam (LY127935), azlocillin, mezlocillin, and piperacillin, and with seven older beta-lactam antibiotics. All the drugs were active against beta-lactamase-negative strains of N. gonorrhoeae and H. influenzae. The drug most active against beta-lactamase-positive N. gonorrhoeae was cefotaxime, followed closely by cefoperazone, moxalactam, piperacillin, and mezlocillin. The drugs most active against beta-lactamase-positive strains of H. influenzae were cefotaxime, moxalactam, cefoperazone, and cefamandole.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry A. L., Thornsberry C., Jones R. N., Fuchs P. C., Gavan T. L., Gerlach E. H. Cefuroxime, an in vitro Comparison with Six Other Cephalosporins. Proc R Soc Med. 1977;70(Suppl 9):63–71. [PMC free article] [PubMed] [Google Scholar]
  2. Biddle J. W., Swenson J. M., Thornsberry C. Disc agar diffusion antimicrobial susceptibility tests with beta-lactamase producing Neisseria gonorrhoeae. J Antibiot (Tokyo) 1978 Apr;31(4):352–358. doi: 10.7164/antibiotics.31.352. [DOI] [PubMed] [Google Scholar]
  3. Fu K. P., Neu H. C. beta-lactamase stability of HR 756, a novel cephalosporin, compared to that of cefuroxime and cefoxitin. Antimicrob Agents Chemother. 1978 Sep;14(3):322–326. doi: 10.1128/aac.14.3.322. [DOI] [PMC free article] [PubMed] [Google Scholar]
  4. Jaffe H. W., Biddle J. W., Thornsberry C., Johnson R. E., Kaufman R. E., Reynolds G. H., Wiesner P. J. National gonorrhea therapy monitoring study: in vitro antibiotic susceptibility and its correlation with treatment results. N Engl J Med. 1976 Jan 1;294(1):5–9. doi: 10.1056/NEJM197601012940102. [DOI] [PubMed] [Google Scholar]
  5. Jones R. N., Fuchs P. C., Barry A. L., Gavan T. L., Sommers H. M., Gerlach E. H. Cefoperazone (T-1551), a new semisynthetic cephalosporin: comparison with cephalothin and gentamicin. Antimicrob Agents Chemother. 1980 Apr;17(4):743–749. doi: 10.1128/aac.17.4.743. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Medeiros A. A., O'Brien T. F. Ampicillin-resistant Haemophilus influenzae type B possessing a TEM-type beta-lactamase but little permeability barrier to ampicillin. Lancet. 1975 Mar 29;1(7909):716–719. doi: 10.1016/s0140-6736(75)91630-x. [DOI] [PubMed] [Google Scholar]
  7. Murray P. R., Christman J. L., Medoff G. In vitro activity of HR 756, a new cephalosporin, against Neisseria gonorrhoeae. Antimicrob Agents Chemother. 1979 Mar;15(3):452–454. doi: 10.1128/aac.15.3.452. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Percival A., Rowlands J., Corkill J. E., Alergant C. D., Arya O. P., Rees E., Annels E. H. Penicillinase-producing Gonococci in Liverpool. Lancet. 1976 Dec 25;2(8000):1379–1382. doi: 10.1016/s0140-6736(76)91919-x. [DOI] [PubMed] [Google Scholar]
  9. Phillips I. Beta-lactamase-producing, penicillin-resistant gonococcus. Lancet. 1976 Sep 25;2(7987):656–657. doi: 10.1016/s0140-6736(76)92466-1. [DOI] [PubMed] [Google Scholar]
  10. Piot P., van Dyck E., Colaert J., Ursi J. P., Bosmans E., Meheus A. Antibiotic susceptibility of Neisseria gonorrhoeae strains from Europe and Africa. Antimicrob Agents Chemother. 1979 Apr;15(4):535–539. doi: 10.1128/aac.15.4.535. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Siegel M. S., Thompson S. E., Perine P. L., Brown S. T., Reynolds G., Thornsberry C. Treatment of uncomplicated gonococcal urethritis with cefoxitin: comparison with penicillin. Rev Infect Dis. 1979 Jan-Feb;1(1):183–188. doi: 10.1093/clinids/1.1.183. [DOI] [PubMed] [Google Scholar]
  12. Thomas W. J., McReynolds J. W., Mock C. R., Bailey D. W. Letter: Ampicillin-resistant Haemophilus influenzae meningitis. Lancet. 1974 Feb 23;1(7852):313–313. doi: 10.1016/s0140-6736(74)92617-8. [DOI] [PubMed] [Google Scholar]
  13. Thornsberry C., Baker C. N., Jones R. N. In vitro antimicrobial activity of piperacillin and seven other beta-lactam antibiotics against Neisseria gonorrhoeae and Haemophilus influenzae, including beta-lactamase producing strains. J Antimicrob Chemother. 1979 Mar;5(2):137–142. doi: 10.1093/jac/5.2.137. [DOI] [PubMed] [Google Scholar]
  14. Thornsberry C., Baker C. N., Kirven L. A., Swenson J. M. Susceptibility of ampicillin-resistant Haemophilus influenzae to seven penicillins. Antimicrob Agents Chemother. 1976 Jan;9(1):70–73. doi: 10.1128/aac.9.1.70. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Watts B. A., Phillips I., Stoate M. W. The in vitro activity of 15 penicillins and mecillinam against Neisseria gonorrhoeae. J Antimicrob Chemother. 1977 Jul;3(4):331–337. doi: 10.1093/jac/3.4.331. [DOI] [PubMed] [Google Scholar]
  16. Wise R., Gillett A. P., Andrews J. M., Bedford K. A. Activity of azlocillin and mezlocillin against gram-negative organisms: comparison with other penicillins. Antimicrob Agents Chemother. 1978 Apr;13(4):559–565. doi: 10.1128/aac.13.4.559. [DOI] [PMC free article] [PubMed] [Google Scholar]

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