Abstract
Fatty acids cause a decrease in the absorption spectra of the antifungal polyene macrolide antibiotics nystatin, filipin, candicidin, and amphotericin B. For nystatin, filipin, and candicidin, this decrease in absorption could be correlated with the activity of the fatty acids in protecting the yeast Saccharomyces cerevisiae against the action of these antibiotics. With amphotericin B a correlation was observed between the decrease in absorption caused by certain derivatives of fatty acids and the protective action of these derivatives against the activity of amphotericin B on yeast. It is concluded that, like the sterols, fatty acids also interact with the polyene antibiotics and thereby reduce their effective concentrations.
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Selected References
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- Bittman R., Fischkoff S. A. Fluorescence studies of the binding of the polyene antibiotics filipin 3, amphotericin B, nystatin, and lagosin to cholesterol. Proc Natl Acad Sci U S A. 1972 Dec;69(12):3795–3799. doi: 10.1073/pnas.69.12.3795. [DOI] [PMC free article] [PubMed] [Google Scholar]
- GHOSH A., GHOSH J. J. Factors affecting the absorption of nystatin by Candida albicans. Ann Biochem Exp Med. 1963 Mar;23:101–112. [PubMed] [Google Scholar]
- HICKEY R. J. The antagonism between the antifungal antibiotic, ascosin, and some long-chain, unsaturated fatty acids. Arch Biochem Biophys. 1953 Oct;46(2):331–336. doi: 10.1016/0003-9861(53)90205-7. [DOI] [PubMed] [Google Scholar]
- Hamilton-Miller J. M. Chemistry and biology of the polyene macrolide antibiotics. Bacteriol Rev. 1973 Jun;37(2):166–196. [PMC free article] [PubMed] [Google Scholar]
- Hammond S. M., Kliger B. N. Mode of action of the polyene antibiotic candicidin: binding factors in the wall of Candida albicans. Antimicrob Agents Chemother. 1976 Apr;9(4):561–568. doi: 10.1128/aac.9.4.561. [DOI] [PMC free article] [PubMed] [Google Scholar]
- LAMPEN J. O., ARNOW P. M., SAFFERMAN R. S. Mechanism of protection by sterols against polyene antibiotics. J Bacteriol. 1960 Aug;80:200–206. doi: 10.1128/jb.80.2.200-206.1960. [DOI] [PMC free article] [PubMed] [Google Scholar]
- OROSHNIK W., MEBANE A. D. THE POLYENE ANTIFUNGAL ANTIBIOTICS. Fortschr Chem Org Naturst. 1963;21:17–79. doi: 10.1007/978-3-7091-7149-3_2. [DOI] [PubMed] [Google Scholar]
- Sarachek A., Higgins N. P. Effects of ergosterol, palmitic acid and related simple lipids on the recovery of Candida albicans from ultraviolet irradiation. Arch Mikrobiol. 1972;82(1):38–54. doi: 10.1007/BF00424928. [DOI] [PubMed] [Google Scholar]