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. 1980 Jul;18(1):9–12. doi: 10.1128/aac.18.1.9

In vitro antimicrobial susceptibility of Actinobacillus actinomycetemcomitans.

J Slots, R T Evans, P M Lobbins, R J Genco
PMCID: PMC283931  PMID: 6903116

Abstract

The agar dilution technique was used for determination of the antibiotic susceptibilities of 57 oral isolates and 2 nonoral isolates of Actinobacillus actinomycetemcomitans. Tetracycline, minocycline, and chloramphenicol inhibited more than 96% of the strains tested at a concentration of less than or equal to 2 micrograms/ml; 89% of the strains were inhibited by 2 micrograms of carbenicillin per ml. The other antimicrobial agents tested were less active. Approximately 10% of the A. actinomycetemcomitans strains were resistant to ampicillin, erythromycin, and penicillin G at concentrations of 32 to 64 micrograms/ml. These data suggest that tetracycline and minocycline may be valuable drugs in the treatment of A. actinomycetemcomitans infections.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. BREDE H. D. Zur Aetiologie und Mikrobiologie der Aktionomykose. I. Invitro-Versuche zur Frage der fermentativen Unterstützung des Actinomyces israeli durch Begleitbakterien. Zentralbl Bakteriol Orig. 1959 Jan;174(1-2):110–122. [PubMed] [Google Scholar]
  2. Bartlett J. G., Sutter V. L., Finegold S. M. Treatment of anaerobic infections with lincomycin and clindamycin. N Engl J Med. 1972 Nov 16;287(20):1006–1010. doi: 10.1056/NEJM197211162872002. [DOI] [PubMed] [Google Scholar]
  3. Block P. J., Yoran C., Fox A. C., Kaltman A. J. Actinobacillus actinomycetemcomitans endocarditis: report of a case and review of the literature. Am J Med Sci. 1973 Nov;266(5):387–392. doi: 10.1097/00000441-197311000-00006. [DOI] [PubMed] [Google Scholar]
  4. Burgher L. W., Loomis G. W., Ware F. Systemic infection due to Actinobacillus actinomycetemcomitans. Am J Clin Pathol. 1973 Sep;60(3):412–415. doi: 10.1093/ajcp/60.3.412. [DOI] [PubMed] [Google Scholar]
  5. Ellner J. J., Rosenthal M. S., Lerner P. I., McHenry M. C. Infective endocarditis caused by slow-growing, fastidious, Gram-negative bacteria. Medicine (Baltimore) 1979 Mar;58(2):145–158. doi: 10.1097/00005792-197903000-00003. [DOI] [PubMed] [Google Scholar]
  6. Fritsche D. Untersuchungen über die Empfindlichkeit des Actinomyces israeli und zwei seiner häufigsten anaeroben Begleitbakterien gegen neuere Antibiotica (6-D-alpha-Aminobenzylpenicillin, Aminosidin, Colistin, Kanamycin, Novobiocin, Oleandomycin, Spiramycin, Vancomycin) Z Hyg Infektionskr. 1964;150(1):50–57. [PubMed] [Google Scholar]
  7. HEINRICH S., PULVERER G. [On the etiology and microbiology of actinomycosis. III. The pathogenic significance of Actinobacillus actinomycetem-comitans among the "bacterial symbionts" of Actinomyces israeli]. Zentralbl Bakteriol. 1959 Sep;176:91–101. [PubMed] [Google Scholar]
  8. HOLM P. Studies on the aetiology of human actinomycosis. II. Do the other microbes of actinomycosis possess virulence? Acta Pathol Microbiol Scand. 1951;28(4):391–406. doi: 10.1111/j.1699-0463.1951.tb03705.x. [DOI] [PubMed] [Google Scholar]
  9. KING E. O., TATUM H. W. Actinobacillus actinomycetemcomitans and Hemophilus aphrophilus. J Infect Dis. 1962 Sep-Oct;111:85–94. doi: 10.1093/infdis/111.2.85. [DOI] [PubMed] [Google Scholar]
  10. MITCHELL R. G., GILLESPIE W. A. BACTERIAL ENDOCARDITIS DUE TO AN ACTINOBACILLUS. J Clin Pathol. 1964 Sep;17:511–512. doi: 10.1136/jcp.17.5.511. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Martin B. F., Derby B. M., Budzilovich G. N., Ransohoff J. Brain abscess due to Actinobacillus actinomycetemcomitans. Neurology. 1967 Sep;17(9):833–837. doi: 10.1212/wnl.17.9.833. [DOI] [PubMed] [Google Scholar]
  12. Muhle I., Rau J., Ruskin J. Vertebral osteomyelitis due to Actinobacillus actinomycetemcomitans. JAMA. 1979 Apr 27;241(17):1824–1825. [PubMed] [Google Scholar]
  13. Overholt B. F. Actinobacillus actinomycetemcomitans endocarditis. Arch Intern Med. 1966 Jan;117(1):99–102. [PubMed] [Google Scholar]
  14. Page M. I., King E. O. Infection due to Actinobacillus actinomycetemcomitans and Haemophilus aphrophilus. N Engl J Med. 1966 Jul 28;275(4):181–188. doi: 10.1056/NEJM196607282750403. [DOI] [PubMed] [Google Scholar]
  15. Rosenblatt J. E., Neumann A. M. A rapid slide test for penicillinase. Am J Clin Pathol. 1978 Mar;69(3):351–354. doi: 10.1093/ajcp/69.1.351. [DOI] [PubMed] [Google Scholar]
  16. Serra P., Tonato M. Subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans. Am J Med. 1969 Nov;47(5):809–812. doi: 10.1016/0002-9343(69)90174-0. [DOI] [PubMed] [Google Scholar]
  17. Spieckermann C. Die In-vitro-Empfindlichkeit von Actinomyces israelii, Actino bacillus actinomycetem-comitans und Bacteroides melaninogenicus gegen-uber Cephlothin, Cephaloridin, Gentamycin, Fusininsäure und Lincomycin. Int Z Klin Pharmakol Ther Toxikol. 1970 Oct;4(4):318–320. [PubMed] [Google Scholar]
  18. Sutter V. L., Finegold S. M. Haemophilus aphrophilus infections: clinical and bacteriologic studies. Ann N Y Acad Sci. 1970 Oct 30;174(2):468–487. doi: 10.1111/j.1749-6632.1970.tb45574.x. [DOI] [PubMed] [Google Scholar]
  19. THJØTTA T., SYDNES S. Actinobacillus actinomycetam comitans as the sole infecting agent in a human being. Acta Pathol Microbiol Scand. 1951;28(1):27–35. doi: 10.1111/j.1699-0463.1951.tb04998.x. [DOI] [PubMed] [Google Scholar]
  20. Tanner A. C., Haffer C., Bratthall G. T., Visconti R. A., Socransky S. S. A study of the bacteria associated with advancing periodontitis in man. J Clin Periodontol. 1979 Oct;6(5):278–307. doi: 10.1111/j.1600-051x.1979.tb01931.x. [DOI] [PubMed] [Google Scholar]
  21. Townsend T. R., Gillenwater J. Y. Urinary tract infection due to Actinobacillus actinomycetemcomitans. JAMA. 1969 Oct 20;210(3):558–558. [PubMed] [Google Scholar]
  22. Vandepitte J., De Geest H., Jousten P. Subacute bacterial endocarditis due to Actinobacillus actinomycetemcomitans. Report of a case with a review of the literature. J Clin Pathol. 1977 Sep;30(9):842–846. doi: 10.1136/jcp.30.9.842. [DOI] [PMC free article] [PubMed] [Google Scholar]
  23. Vogelzang R. M. Bacterial endocarditis due to Actinobacillus actinomycetemcomitans. Arch Intern Med. 1967 Jul;120(1):99–101. [PubMed] [Google Scholar]
  24. Wilkins T. D., Chalgren S. Medium for use in antibiotic susceptibility testing of anaerobic bacteria. Antimicrob Agents Chemother. 1976 Dec;10(6):926–928. doi: 10.1128/aac.10.6.926. [DOI] [PMC free article] [PubMed] [Google Scholar]

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