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. 1980 Jul;18(1):190–194. doi: 10.1128/aac.18.1.190

In vitro susceptibility testing of Paracoccidioides brasiliensis to sulfonamides.

A Restrepo, M D Arango
PMCID: PMC283962  PMID: 7416744

Abstract

A total of 60 clinical isolates of Paracoccidioides brasiliensis were tested for susceptibility to sulfadiazine and sulfadimethoxyne by the agar dilution technique. A modification of the Mueller-Hinton medium was devised which gave good growth of the yeast form. The minimum inhibitory concentrations for only 51.6% of the isolates were in the range of the recommended blood serum concentration (50 micrograms/ml). For 6 to 8% of the isolates, the minimum inhibitory concentrations were above 200 micrograms of both sulfadiazine and sulfadimethoxyne per ml. A significant decreases in susceptibility was demonstrated for one isolate obtained from a patient relapsing during sulfonamide therapy.

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Selected References

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