Abstract
A total of 60 clinical isolates of Paracoccidioides brasiliensis were tested for susceptibility to sulfadiazine and sulfadimethoxyne by the agar dilution technique. A modification of the Mueller-Hinton medium was devised which gave good growth of the yeast form. The minimum inhibitory concentrations for only 51.6% of the isolates were in the range of the recommended blood serum concentration (50 micrograms/ml). For 6 to 8% of the isolates, the minimum inhibitory concentrations were above 200 micrograms of both sulfadiazine and sulfadimethoxyne per ml. A significant decreases in susceptibility was demonstrated for one isolate obtained from a patient relapsing during sulfonamide therapy.
Full text
PDF




Images in this article
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- BAUER A. W., SHERRIS J. C. THE DETERMINATION OF SULFONAMIDE SUSCEPTIBILITY OF BACTERIA. Chemotherapy. 1964;9(1):1–19. doi: 10.1159/000220337. [DOI] [PubMed] [Google Scholar]
- Hammerberg S., Marks M. I., Weinmaster G. Reevaluation of the disk diffusion method for sulfonamide susceptibility testing of Neisseria meningitidis. Antimicrob Agents Chemother. 1976 Dec;10(6):869–871. doi: 10.1128/aac.10.6.869. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Lehrer R. I. The fungicidal mechanisms of human monocytes. I. Evidence for myeloperoxidase-linked and myeloperoxidase-independent candidacidal mechanisms. J Clin Invest. 1975 Feb;55(2):338–346. doi: 10.1172/JCI107937. [DOI] [PMC free article] [PubMed] [Google Scholar]
- MACKINNON J. E., SANJINES A., ARTAGAVEYTIA-ALLENDE R. C. Quimioterapia de la blastomicosis Sudamericana; ensayo in vitro de cuatro diamidinas aromáticas, dos sulfamidas, una sulfona y un antihistamïnico; ensayo clïnico de la diamidinodifenilamina. An Fac Med Univ Repub Montev Urug. 1957 Sep-Dec;42(5-6):131–142. [PubMed] [Google Scholar]
- MARIAT F., SATRE J. [The action of sulfamethoxypyridazine on some pathogenic aerobic actinomycetes]. Bull Soc Pathol Exot Filiales. 1961 Jan-Feb;54:63–70. [PubMed] [Google Scholar]
- Negroni P., Negroni R. Nuestra experiencia de la blastomicosis sudamericana en la Argentina. Mycopathol Mycol Appl. 1965 Aug 10;26(2):264–272. doi: 10.1007/BF02049780. [DOI] [PubMed] [Google Scholar]
- Restrepo-Moreno A., Schneidau J. D., Jr Nature of the skin-reactive principle in culture filtrates prepared from Paracoccidioides brasiliensis. J Bacteriol. 1967 Jun;93(6):1741–1748. doi: 10.1128/jb.93.6.1741-1748.1967. [DOI] [PMC free article] [PubMed] [Google Scholar]
- SAMPAIO S. A., DA LACAZ C. S., BOLOGNANI FILHO H. Aço do sulfisoxazol na blastomicose Sul-Americana. Rev Assoc Med Bras. 1955 Oct;2(1):33–36. [PubMed] [Google Scholar]
- Shadomy S. In vitro studies with 5-fluorocytosine. Appl Microbiol. 1969 Jun;17(6):871–877. doi: 10.1128/am.17.6.871-877.1969. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Stevens D. Miconazole in the treatment of systemic fungal infections. Am Rev Respir Dis. 1977 Nov;116(5):801–806. doi: 10.1164/arrd.1977.116.5.801. [DOI] [PubMed] [Google Scholar]
- de AREA LEAO A. E., CURY A. Deficiencias vitaminicas de cogumelos patogenicos. Mycopathol Mycol Appl. 1950 Mar 25;5(1):65–90. [PubMed] [Google Scholar]