Abstract
For identifying drugs which might be effective in the treatment of human Babesia microti infections, 20 selected antiprotozoal agents or combinations of agents were tested for activity against B. microti in Mongolian jirds (meriones unguiculatus). 4-Methyl-primaquine and aromatic diamidines, including diminazene and pentamidine, were the most effective compounds tested.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Gleason N. N., Wolf R. E. Entopolypoides macaci (Babesiidae) in Macaca mulatta. J Parasitol. 1974 Oct;60(5):844–847. [PubMed] [Google Scholar]
- Kinnamon K. E., Steck E. A., Loizeaux P. S., Hanson W. L., Chapman W. L., Jr, Waits V. B. The antileishmanial activity of lepidines. Am J Trop Med Hyg. 1978 Jul;27(4):751–757. doi: 10.4269/ajtmh.1978.27.751. [DOI] [PubMed] [Google Scholar]
- Miller L. H., Neva F. A., Gill F. Failure of chloroquine in human babesiosis (Babesia microti): case report and chemotherapeutic trials in hamsters. Ann Intern Med. 1978 Feb;88(2):200–202. doi: 10.7326/0003-4819-88-2-200. [DOI] [PubMed] [Google Scholar]
- Ruebush T. K., 2nd, Collins W. E., Healy G. R., Warren M. Experimental Babesia microti infections in non-splenectomized Macaca mulatta. J Parasitol. 1979 Feb;65(1):144–146. [PubMed] [Google Scholar]
- Ruebush T. K., 2nd, Juranek D. D., Chisholm E. S., Snow P. C., Healy G. R., Sulzer A. J. Human babesiosis on Nantucket Island. Evidence for self-limited and subclinical infections. N Engl J Med. 1977 Oct 13;297(15):825–827. doi: 10.1056/NEJM197710132971511. [DOI] [PubMed] [Google Scholar]
- Ruebush T. K., 2nd, Rubin R. H., Wolpow E. R., Cassaday P. B., Schultz M. G. Neurologic complications following the treatment of human Babesia microti infection with diminazene aceturate. Am J Trop Med Hyg. 1979 Mar;28(2):184–189. doi: 10.4269/ajtmh.1979.28.184. [DOI] [PubMed] [Google Scholar]
- Western K. A., Benson G. D., Gleason N. N., Healy G. R., Schultz M. G. Babesiosis in a Massachusetts resident. N Engl J Med. 1970 Oct 15;283(16):854–856. doi: 10.1056/NEJM197010152831607. [DOI] [PubMed] [Google Scholar]