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. 1980 Sep;18(3):487–490. doi: 10.1128/aac.18.3.487

Tentative interpretive criteria for the diffusion susceptibility test using 30-microgram netilmicin disks.

R N Jones, A L Barry, C Thornsberry
PMCID: PMC284029  PMID: 7425615

Abstract

The disk diffusion inhibitory zone diameters for 10-microgram and 30-microgram netilmicin disks were correlated with minimum inhibitory concentrations against 471 clinical strains tested in cation-supplemented Mueller-Hinton broth. Regression line and error-rate bounded analysis favored the use of 30-microgram netilmicin disks utilizing zone size breakpoints of greater than or equal to 17 mm to indicate susceptibility (less than or equal to 8 microgram/ml) and less than or equal to 13 mm to indicate resistance (greater than 32 microgram/ml). Significant minor interpretive errors may be expected when testing populations of Pseudomonas that have netilmicin minimum inhibitory concentrations near the intermediate range (16 microgram/ml).

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barry A. L., Thornsberry C., Badal R. E., Baker C. N., Jones R. N., Gerlach E. H. Piperacillin susceptibility tests by the single-disk agar diffusion technique. Antimicrob Agents Chemother. 1979 Sep;16(3):378–385. doi: 10.1128/aac.16.3.378. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Barry A. L., Thornsberry C., Jones R. N., Fuchs P. C., Gavan T. L., Gerlach E. H. Reassessment of the "class" concept of disk susceptibility testing. Cephalothin disks versus minimal inhibitory concentrations with eleven cephalosporins. Am J Clin Pathol. 1978 Dec;70(6):909–913. doi: 10.1093/ajcp/70.6.909. [DOI] [PubMed] [Google Scholar]
  3. Bauer A. W., Kirby W. M., Sherris J. C., Turck M. Antibiotic susceptibility testing by a standardized single disk method. Am J Clin Pathol. 1966 Apr;45(4):493–496. [PubMed] [Google Scholar]
  4. Brummett R. E., Fox K. E., Brown R. T., Himes D. L. Comparative ototoxic liability of netilmicin and gentamicin. Arch Otolaryngol. 1978 Oct;104(10):579–584. doi: 10.1001/archotol.1978.00790100033007. [DOI] [PubMed] [Google Scholar]
  5. Fu K. P., Neu H. C. Correlation of netilmicin disk diffusion susceptibility and agar dilution susceptibility. Antimicrob Agents Chemother. 1979 Jun;15(6):834–835. doi: 10.1128/aac.15.6.834. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Goldmann D. A., Syriopoulou G. P., Semple A. M. Correlation of netilmicin agar dilution and disk diffusion susceptibilities. Antimicrob Agents Chemother. 1977 Aug;12(2):288–289. doi: 10.1128/aac.12.2.288. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Habwe V., Shadomy S. In vitro susceptibility studies with netilmicin: comparison of a 10-microgram netilmicin disk with a standardized 10-microgram gentamicin disk. Antimicrob Agents Chemother. 1978 Jun;13(6):1046–1048. doi: 10.1128/aac.13.6.1046. [DOI] [PMC free article] [PubMed] [Google Scholar]
  8. Humbert G., Leroy A., Fillastre J. P., Oksenhendler G. Pharmacokinetics of netilmicin in the presence of normal or impaired renal function. Antimicrob Agents Chemother. 1978 Jul;14(1):40–44. doi: 10.1128/aac.14.1.40. [DOI] [PMC free article] [PubMed] [Google Scholar]
  9. Klastersky J., Meunier-Carpentier F., Coppens-Kahan L., Daneau D., Prevost J. M. Clinical and bacteriological evaluation of netilmicin in gram-negative infections. Antimicrob Agents Chemother. 1977 Oct;12(4):503–509. doi: 10.1128/aac.12.4.503. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. Luft F. C., Yum M. N., Kleit S. A. Comparative nephrotoxicities of netilmicin and gentamicin in rats. Antimicrob Agents Chemother. 1976 Nov;10(5):845–849. doi: 10.1128/aac.10.5.845. [DOI] [PMC free article] [PubMed] [Google Scholar]
  11. Metzler C. M., DeHaan R. M. Susceptibility tests of anaerobic bacteria: statistical and clinical considerations. J Infect Dis. 1974 Dec;130(6):588–594. doi: 10.1093/infdis/130.6.588. [DOI] [PubMed] [Google Scholar]
  12. Meyers B. R., Hirschman S. Z., Wormser G., Siegel D. Pharmacokinetic study of netilmicin. Antimicrob Agents Chemother. 1977 Jul;12(1):122–123. doi: 10.1128/aac.12.1.122. [DOI] [PMC free article] [PubMed] [Google Scholar]
  13. Miller G. H., Arcieri G., Weinstein M. J., Waitz J. A. Biological activity of netilmicin, a broad-spectrum semisynthetic aminoglycoside antibiotic. Antimicrob Agents Chemother. 1976 Nov;10(5):827–836. doi: 10.1128/aac.10.5.827. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Phillips I., Smith A., Shannon K. Antibacterial activity of netilmicin, a new aminoglycoside antibiotic, compared with that of gentamicin. Antimicrob Agents Chemother. 1977 Mar;11(3):402–406. doi: 10.1128/aac.11.3.402. [DOI] [PMC free article] [PubMed] [Google Scholar]
  15. Rahal J. J., Jr, Simberkoff M. S., Kagan K., Moldover N. H. Bactericidal efficacy of Sch 20569 and amikacin against gentamicin-sensitive and -resistant organisms. Antimicrob Agents Chemother. 1976 Apr;9(4):595–599. doi: 10.1128/aac.9.4.595. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Siegel J. D., McCracken G. H., Jr, Thomas M. L., Threlkeld N. Pharmacokinetic properties of netilmicin in newborn infants. Antimicrob Agents Chemother. 1979 Feb;15(2):246–253. doi: 10.1128/aac.15.2.246. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. Trestman I., Parsons J., Santoro J., Goodhart G., Kaye D. Pharmacology and efficacy of netilmicin. Antimicrob Agents Chemother. 1978 May;13(5):832–836. doi: 10.1128/aac.13.5.832. [DOI] [PMC free article] [PubMed] [Google Scholar]

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