Abstract
In susceptible strain of Bacteroides fragilis, tetracycline uptake is biphasic. The initial phase is independent of adenosine 5'-triphosphate synthesis, which is coupled to fumarate reduction; this phase is not altered by expression of tetracycline resistance genes in a resistant strain. The second phase appears to occur by active transport, since it is largely reduced by rotenone, an inhibitor of electron transport to fumarate; moreover, this phase is under negative control of the tetracycline resistance gene.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Chopra I., Howe T. G. Bacterial resistance to the tetracyclines. Microbiol Rev. 1978 Dec;42(4):707–724. doi: 10.1128/mr.42.4.707-724.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- De Zeeuw J. R. Accumulation of tetracyclines by Escherichia coli. J Bacteriol. 1968 Feb;95(2):498–506. doi: 10.1128/jb.95.2.498-506.1968. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Harris M. A., Reddy C. A. Hydrogenase activity and the H2-fumarate electron transport system in Bacteroides fragilis. J Bacteriol. 1977 Sep;131(3):922–928. doi: 10.1128/jb.131.3.922-928.1977. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Levy S. B., McMurry L. Plasmid-determined tetracycline resistance involves new transport systems for tetracycline. Nature. 1978 Nov 2;276(5683):90–92. doi: 10.1038/276090a0. [DOI] [PubMed] [Google Scholar]
- Macy J. M., Ljungdahl L. G., Gottschalk G. Pathway of succinate and propionate formation in Bacteroides fragilis. J Bacteriol. 1978 Apr;134(1):84–91. doi: 10.1128/jb.134.1.84-91.1978. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Macy J., Probst I., Gottschalk G. Evidence for cytochrome involvement in fumarate reduction and adenosine 5'-triphosphate synthesis by Bacteroides fragilis grown in the presence of hemin. J Bacteriol. 1975 Aug;123(2):436–442. doi: 10.1128/jb.123.2.436-442.1975. [DOI] [PMC free article] [PubMed] [Google Scholar]
- McMurry L., Levy S. B. Two transport systems for tetracycline in sensitive Escherichia coli: critical role for an initial rapid uptake system insensitive to energy inhibitors. Antimicrob Agents Chemother. 1978 Aug;14(2):201–209. doi: 10.1128/aac.14.2.201. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Privitera G., Sebald M., Fayolle F. Common regulatory mechanism of expression and conjugative ability of a tetracycline resistance plasmid in Bacteroides fragilis. Nature. 1979 Apr 12;278(5705):657–659. doi: 10.1038/278657a0. [DOI] [PubMed] [Google Scholar]