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. 1980 Nov;18(5):661–666. doi: 10.1128/aac.18.5.661

Effect of prednisolone and rifampin on isoniazid metabolism in slow and rapid inactivators of isoniazid.

G R Sarma, S Kailasam, N G Nair, A S Narayana, S P Tripathy
PMCID: PMC284072  PMID: 7447424

Abstract

The effect of prednisolone and rifampin, alone and in combination, on the biodisposition of isoniazid in slow and rapid inactivators of isoniazid was investigated. In one investigation, we made serial determinations of plasma isoniazid concentrations up to 8 h and of isoniazid and acetylisoniazid in excreted urine up to 8.5 h in patients receiving isoniazid alone on one occasion and isoniazid plus prednisolone or isoniazid plus rifampin on another. Prednisolone caused a significant decrease in the plasma isoniazid concentrations in both slow and rapid inactivators. It also enhanced the renal clearance of isoniazid in both slow and rapid inactivators and increased the rate of acetylation of isoniazid in slow inactivators only. Rifampin had no effect on the biodisposition of isoniazid in either slow or rapid inactivators. In a second investigation, one group of slow and rapid inactivators received isoniazid and rifampin, and a different group received prednisolone, in addition. Plasma isoniazid concentrations in slow inactivators receiving prednisolone were significantly lower than in those who received isoniazid and rifampin only. In rapid inactivators, plasma isoniazid concentrations were similar in the two groups of patients, suggesting that concomitant administration of rifampin had considerably modified the prednisolone effect on the biodisposition of isoniazid in these patients.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Acocella G., Bonollo L., Garimoldi M., Mainardi M., Tenconi L. T., Nicolis F. B. Kinetics of rifampicin and isoniazid administered alone and in combination to normal subjects and patients with liver disease. Gut. 1972 Jan;13(1):47–53. doi: 10.1136/gut.13.1.47. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Boman G. Serum concentration and half-life of rifampicin after simultaneous oral administration of aminosalicylic acid or isoniazid. Eur J Clin Pharmacol. 1974;7(3):217–225. doi: 10.1007/BF00560384. [DOI] [PubMed] [Google Scholar]
  3. Buffington G. A., Dominguez J. H., Piering W. F., Hebert L. A., Kauffman H. M., Jr, Lemann J., Jr Interaction of rifampin and glucocorticoids. Adverse effect on renal allograft function. JAMA. 1976 Oct 25;236(17):1958–1960. [PubMed] [Google Scholar]
  4. Crawford J. S., Rudofsky S. Some alterations in the pattern of drug metabolism aociated with pegnancy, oral contraceptives, and the newly-born. Br J Anaesth. 1966 Jun;38(6):446–454. doi: 10.1093/bja/38.6.446. [DOI] [PubMed] [Google Scholar]
  5. EIDUS L., HAMILTON E. J. A NEW METHOD FOR THE DETERMINATION OF N-ACETYL ISONIAZID IN URINE OF AMBULATORY PATIENTS. Am Rev Respir Dis. 1964 Apr;89:587–588. doi: 10.1164/arrd.1964.89.4.587. [DOI] [PubMed] [Google Scholar]
  6. Edwards O. M., Courtenay-Evans R. J., Galley J. M., Hunter J., Tait A. D. Changes in cortisol metabolism following rifampicin therapy. Lancet. 1974 Sep 7;2(7880):548–551. [PubMed] [Google Scholar]
  7. Ellard G. A., Gammon P. T. Pharmacokinetics of isoniazid metabolism in man. J Pharmacokinet Biopharm. 1976 Apr;4(2):83–113. doi: 10.1007/BF01086149. [DOI] [PubMed] [Google Scholar]
  8. Ellard G. A., Gammon P. T., Tiitinen H. Determination of the acetylator phenotype from the ratio of the urinary excretion of acetylisoniazid to acid-labile isoniazid: a study in Finnish Lapland. Tubercle. 1973 Sep;54(3):201–210. doi: 10.1016/0041-3879(73)90025-1. [DOI] [PubMed] [Google Scholar]
  9. Gelber R. H., Gool H. C., Rees R. J. The effect of rifampicin on dapsone metabolism. Proc West Pharmacol Soc. 1975;18:330–334. [PubMed] [Google Scholar]
  10. Hayakawa T., Kanai N., Yamada R., Kuroda R., Higashi H., Mogami H., Jinnai D. Effect of steroid hormone on activation of Endoxan (cyclophosphamide). Biochem Pharmacol. 1969 Jan;18(1):129–135. doi: 10.1016/0006-2952(69)90017-3. [DOI] [PubMed] [Google Scholar]
  11. JENNE J. W., MACDONALD F. M., MENDOZA E. A study of the renal clearances, metabolic inactivation rates, and serum fall-off interaction of isoniazid and paraminosalicylic acid in man. Am Rev Respir Dis. 1961 Sep;84:371–378. doi: 10.1164/arrd.1961.84.3.371. [DOI] [PubMed] [Google Scholar]
  12. Kailasam S., Immanuel C., Nair N. G., Radhakrishma S., Tripathy S. P. Classification of subjects as slow or rapid inactivators of isoniazid oral administration of a slow-release preparation of isoniazid and determination of the ratio of acetylisoniazid to isoniazid in urine. Indian J Med Res. 1975 Feb;63(2):323–328. [PubMed] [Google Scholar]
  13. Klinenberg J. R., Miller F. Effect of corticosteroids on blood salicylate concentration. JAMA. 1965 Nov 8;194(6):601–604. [PubMed] [Google Scholar]
  14. Modai J., Coulaud J. P., Vivien J. M., Berthelot G., Bergogne-Berezin E. Influence de la rifampicine sur le métabolisme de l'isoniazide. Nouv Presse Med. 1978 Apr 15;7(15):1263–1267. [PubMed] [Google Scholar]
  15. Peters U., Hausamen T. U., Grosse-Brockhoff F. Einfluss von Tuberkulostatika auf die Pharmakokinetik des Digitoxins. Dtsch Med Wochenschr. 1974 Nov 22;99(47):2381–2386. doi: 10.1055/s-0028-1108142. [DOI] [PubMed] [Google Scholar]
  16. Rao K. V., Kailasam S., Menon N. K., Radhakrishna S. Inactivation of isoniazid by condensation in a syrup preparation. Bull World Health Organ. 1971;45(5):625–632. [PMC free article] [PubMed] [Google Scholar]
  17. Sarma G. R., Immanuel C., Kailasam S., Kannapiran M., Nair N. G., Radhakrishna S. A modified method for the estimation of acetylisoniazid in urine. Indian J Med Res. 1974 Jun;62(6):945–952. [PubMed] [Google Scholar]

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