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. 1980 Nov;18(5):675–679. doi: 10.1128/aac.18.5.675

Quantitative correlation between penicillin resistance and beta-lactamase activity specified by the R plasmids R1, R1 bla-45, and RP1 in Escherichia coli K-12.

I Crowlesmith, T G Howe
PMCID: PMC284074  PMID: 7004346

Abstract

A mutant of the R plasmid R1 which synthesizes a beta-lactamase with altered kinetic characteristics was isolated. The level of penicillin resistance specified by this plasmid was correctly predicted from the properties of the wild-type R1 according to a simple theoretical model published by Zimmermann and Rosselet (Antimicrob. Agents Chemother. 12:368--372, 1977). The model also accounts for the high level of penicillin resistance specified by the R plasmid RP1.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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