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Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1980 Nov;18(5):753–760. doi: 10.1128/aac.18.5.753

Identification of tetracycline-resistant R-plasmids in Streptococcus agalactiae (group B).

V Burdett
PMCID: PMC284087  PMID: 7004347

Abstract

In this report, 30 tetracycline-resistant clinical isolates of group B Streptococcus were examined to assess the extent to which tetracycline resistance is plasmid mediated. Of these, 27 showed no physical or genetic evidence of plasmid-mediated resistance; however, one conjugative and two small (3.5 X 10(6)-dalton) multicopy non-self-transmissible tetracycline resistance plasmids were identified. The conjugative plasmid was transmissible to Streptococcus faecalis as well as to Streptococcus agalactiae (group B). The two nonconjugative plasmids were readily mobilized by a number of sex factors into these same two backgrounds and, in addition, readily transformed Streptococcus sanguis Challis to tetracycline resistance. Due to readily available sites for several site-specific endonuycleases, these small, multicopy plasmids should prove useful as cloning vehicles in this host system.

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Selected References

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