Abstract
Flucloxacillin, fosfomycin, fusidic acid, teichomycin, and vancomycin were tested against 50 clinical isolates of methicillin-resistant Staphylococcus aureus by a broth macrodilution technique. Teichomycin had a narrow range of activity, similar to that of vancomycin (0.5 to 2.0 micrograms/ml). Fusidic acid had the lowest range of inhibitory activity, with 50 and 90% MICs of 0.19 and 0.35 micrograms/ml, respectively. Flucloxacillin and fosfomycin showed less activity, with MICs up to 32 micrograms/ml.
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- Allona A., Díaz Cabrera J. A., Manchado P. Fosfomycin in chronic urinary infections. Chemotherapy. 1977;23 (Suppl 1):267–274. doi: 10.1159/000222059. [DOI] [PubMed] [Google Scholar]
- Anderson J. D. Fusidic acid: new opportunities with an old antibiotic. Can Med Assoc J. 1980 Apr 5;122(7):765–769. [PMC free article] [PubMed] [Google Scholar]
- BARBER M., WATERWORTH P. M. Antibacterial activity in vitro of fucidin. Lancet. 1962 May 5;1(7236):931–932. doi: 10.1016/s0140-6736(62)91969-4. [DOI] [PubMed] [Google Scholar]
- GODTFREDSEN W., ROHOLT K., TYBRING L. Fucidin: a new orally active antibiotic. Lancet. 1962 May 5;1(7236):928–931. doi: 10.1016/s0140-6736(62)91968-2. [DOI] [PubMed] [Google Scholar]
- Garrod L. P. Methicillin-resistant staphylococci. Lancet. 1968 Oct 19;2(7573):871–871. doi: 10.1016/s0140-6736(68)91028-3. [DOI] [PubMed] [Google Scholar]
- Grüneberg R. N., Emmerson A. M. Failure to prevent emergence of bacterial resistance by combination of two antibiotics: fusidic acid and rifampicin. J Antimicrob Chemother. 1980 Jul;6(4):562–564. doi: 10.1093/jac/6.4.562. [DOI] [PubMed] [Google Scholar]
- Hutzler R., Fernandes V., Muñoz D., Rozentraub A. Activity of fosfomycin in the treatment of bacterial infections. Chemotherapy. 1977;23 (Suppl 1):358–364. doi: 10.1159/000222076. [DOI] [PubMed] [Google Scholar]
- Kahan F. M., Kahan J. S., Cassidy P. J., Kropp H. The mechanism of action of fosfomycin (phosphonomycin). Ann N Y Acad Sci. 1974 May 10;235(0):364–386. doi: 10.1111/j.1749-6632.1974.tb43277.x. [DOI] [PubMed] [Google Scholar]
- Parenti F., Beretta G., Berti M., Arioli V. Teichomycins, new antibiotics from Actinoplanes teichomyceticus Nov. Sp. I. Description of the producer strain, fermentation studies and biological properties. J Antibiot (Tokyo) 1978 Apr;31(4):276–283. doi: 10.7164/antibiotics.31.276. [DOI] [PubMed] [Google Scholar]
- Pattison J. R., Mansell P. E. Fucidin-resistant staphylococci in current hospital practice. J Med Microbiol. 1973 May;6(2):235–244. doi: 10.1099/00222615-6-2-235. [DOI] [PubMed] [Google Scholar]
- Peacock J. E., Jr, Moorman D. R., Wenzel R. P., Mandell G. L. Methicillin-resistant Staphylococcus aureus: microbiologic characteristics, antimicrobial susceptibilities, and assessment of virulence of an epidemic strain. J Infect Dis. 1981 Dec;144(6):575–582. doi: 10.1093/infdis/144.6.575. [DOI] [PubMed] [Google Scholar]
- Price J. D., Harding J. W. Flucloxacillin in the treatment of infectious conditions in children. Curr Med Res Opin. 1975;3(2):77–82. doi: 10.1185/03007997509113651. [DOI] [PubMed] [Google Scholar]
- Rodríguez A., Gallego A., Olay T., Mata J. M. Bacteriological evaluation of fosfomycin in clinical studies. Chemotherapy. 1977;23 (Suppl 1):247–258. doi: 10.1159/000222055. [DOI] [PubMed] [Google Scholar]
- Thompson R. L., Fisher K. A., Wenzel R. P. In vitro activity of N-formimidoyl thienamycin and other beta-lactam antibiotics against methicillin-resistant Staphylococcus aureus. Antimicrob Agents Chemother. 1982 Feb;21(2):341–343. doi: 10.1128/aac.21.2.341. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Thompson R. L., Wenzel R. P. International recognition of methicillin-resistant strains of Staphylococcus aureus. Ann Intern Med. 1982 Dec;97(6):925–926. doi: 10.7326/0003-4819-97-6-925. [DOI] [PubMed] [Google Scholar]
- Thornsberry C., McDougal L. K. Successful use of broth microdilution in susceptibility tests for methicillin-resistant (heteroresistant) staphylococci. J Clin Microbiol. 1983 Nov;18(5):1084–1091. doi: 10.1128/jcm.18.5.1084-1091.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Traub W. H., Kleber I. Interpretation of diffusion susceptibility data obtained with 10-mug fucidin (sodium fusidate) disks against clinical isolates of Staphylococcus aureus. Chemotherapy. 1974;20(2):92–96. doi: 10.1159/000221796. [DOI] [PubMed] [Google Scholar]
- Traub W. H. Variable tolerance of a clinical isolate of Staphylococcus epidermidis from an infected hydrocephalus shunt for several beta-lactam antibiotics, vancomycin and fosfomycin. Chemotherapy. 1981;27(6):432–443. doi: 10.1159/000238013. [DOI] [PubMed] [Google Scholar]
- Unsworth P. F., Heatley F. W., Phillips I. Flucloxacillin in bone. J Clin Pathol. 1978 Aug;31(8):705–711. doi: 10.1136/jcp.31.8.705. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Wenzel R. P. The emergence of methicillin-resistant Staphylococcus aureus. Ann Intern Med. 1982 Sep;97(3):440–442. doi: 10.7326/0003-4819-97-3-440. [DOI] [PubMed] [Google Scholar]