Skip to main content
PMC home page
Antimicrobial Agents and Chemotherapy logoLink to Antimicrobial Agents and Chemotherapy
. 1986 May;29(5):849–851. doi: 10.1128/aac.29.5.849

Dose ranging study of cefpimizole (U-63196E) for treatment of uncomplicated gonorrhea in men.

E T Sandberg, P S Pegram, R E Roddy, H H Handsfield, K D Hampton, K M Shafran, E W Hook 3rd
PMCID: PMC284165  PMID: 3089142

Abstract

We conducted a two-center dose ranging study to evaluate the efficacy, tolerance, and toxicity of cefpimizole, a new cephalosporin, in the treatment of uncomplicated gonorrhea in 96 males. Twelve patients at each center were treated intramuscularly with single doses of 1.0, 0.5, 0.25, and 0.125 g of cefpimizole. All urethral infections were cured at the highest dose, but lower doses produced progressively decreasing cure rates of 90% (0.5 g), 83% (0.25 g), and 71% (0.125 g). Treatment failures of rectal and pharyngeal infections occurred at the highest dose level. Geometric mean MICs for cefpimizole for successfully and unsuccessfully treated volunteers were 0.088 and 0.282 micrograms/ml, respectively. A prominent adverse effect was clinically significant pain at the injection site, which occurred in 57 (59%) of 96 patients. Results of the study demonstrate that cefpimizole offers no advantage over currently available antibiotics in the treatment of uncomplicated gonorrhea in men.

Full text

PDF
849

Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Barnes R. C., Holmes K. K. Epidemiology of gonorrhea: current perspectives. Epidemiol Rev. 1984;6:1–30. doi: 10.1093/oxfordjournals.epirev.a036267. [DOI] [PubMed] [Google Scholar]
  2. Berg S. W., Kilpatrick M. E., Harrison W. O., McCutchan J. A. Cefoxitin as a single-dose treatment for urethritis caused by penicillinase-producing Neisseria gonorrhoeae. N Engl J Med. 1979 Sep 6;301(10):509–511. doi: 10.1056/NEJM197909063011001. [DOI] [PubMed] [Google Scholar]
  3. Bowie W. R. Comparison of Gram stain and first-voided urine sediment in the diagnosis of urethritis. Sex Transm Dis. 1978 Apr-Jun;5(2):39–42. doi: 10.1097/00007435-197804000-00001. [DOI] [PubMed] [Google Scholar]
  4. Collier A. C., Judson F. N., Murphy V. L., Leach L. A., Root C. J., Handsfield H. H. Comparative study of ceftriaxone and spectinomycin in the treatment of uncomplicated gonorrhea in women. Am J Med. 1984 Oct 19;77(4C):68–72. [PubMed] [Google Scholar]
  5. Crider S. R., Colby S. D., Miller L. K., Harrison W. O., Kerbs S. B., Berg S. W. Treatment of penicillin-resistant Neisseria gonorrhoeae with oral norfloxacin. N Engl J Med. 1984 Jul 19;311(3):137–140. doi: 10.1056/NEJM198407193110301. [DOI] [PubMed] [Google Scholar]
  6. Duncan W. C., McBride M. E. Single-dose treatment of uncomplicated gonococcal urethritis: a comparison of cefonicid and penicillin. Sex Transm Dis. 1982 Apr-Jun;9(2):93–95. doi: 10.1097/00007435-198204000-00008. [DOI] [PubMed] [Google Scholar]
  7. Handsfield H. H., Holmes K. K. Treatment of uncomplicated gonorrhea with cefotaxime. Sex Transm Dis. 1981 Jul-Sep;8(3):187–191. doi: 10.1097/00007435-198107000-00003. [DOI] [PubMed] [Google Scholar]
  8. Handsfield H. H. Treatment of uncomplicated gonorrhea in men with single-dose moxalactam. Sex Transm Dis. 1983 Oct-Dec;10(4):191–194. doi: 10.1097/00007435-198311000-00006. [DOI] [PubMed] [Google Scholar]
  9. Handsfield H. H. Treatment of uncomplicated gonorrhea with cefotaxime. Rev Infect Dis. 1982 Sep-Oct;4 (Suppl):S448–S452. doi: 10.1093/clinids/4.supplement_2.s448. [DOI] [PubMed] [Google Scholar]
  10. Holmes K. K., Handsfield H. H., Wang S. P., Wentworth B. B., Turck M., Anderson J. B., Alexander E. R. Etiology of nongonococcal urethritis. N Engl J Med. 1975 Jun 5;292(23):1199–1205. doi: 10.1056/NEJM197506052922301. [DOI] [PubMed] [Google Scholar]
  11. Hook E. W., 3rd, Holmes K. K. Gonococcal infections. Ann Intern Med. 1985 Feb;102(2):229–243. doi: 10.7326/0003-4819-102-2-229. [DOI] [PubMed] [Google Scholar]
  12. Jones R. B., Stimson J., Counts G. W., Holmes K. K. Cefoxitin in the treatment of gonorrhea. Sex Transm Dis. 1979 Oct-Dec;6(4):239–242. doi: 10.1097/00007435-197910000-00002. [DOI] [PubMed] [Google Scholar]
  13. Kim J. H., Ro Y. S., Kim Y. T. Cefoperazone (Cefobid) for treating men with gonorrhoea caused by penicillinase producing Neisseria gonorrhoeae. Br J Vener Dis. 1984 Aug;60(4):238–240. doi: 10.1136/sti.60.4.238. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Kraus S. J. Incidence and therapy of gonococcal pharyngitis. Sex Transm Dis. 1979 Apr-Jun;6(2 Suppl):143–147. doi: 10.1097/00007435-197904000-00019. [DOI] [PubMed] [Google Scholar]
  15. Lossick J. G., Thompson S. E., Smeltzer M. P. Comparison of cefuroxime and penicillin in the treatment of uncomplicated gonorrhea. Antimicrob Agents Chemother. 1982 Sep;22(3):409–413. doi: 10.1128/aac.22.3.409. [DOI] [PMC free article] [PubMed] [Google Scholar]
  16. Neu H. C., Labthavikul P. In vitro activity and beta-lactamase stability of U-63196E, a novel cephalosporin. Antimicrob Agents Chemother. 1983 Sep;24(3):375–382. doi: 10.1128/aac.24.3.375. [DOI] [PMC free article] [PubMed] [Google Scholar]
  17. O'Callaghan C. H., Morris A., Kirby S. M., Shingler A. H. Novel method for detection of beta-lactamases by using a chromogenic cephalosporin substrate. Antimicrob Agents Chemother. 1972 Apr;1(4):283–288. doi: 10.1128/aac.1.4.283. [DOI] [PMC free article] [PubMed] [Google Scholar]
  18. Ridgway G. L., Oriel J. D. Activity of antimicrobials against Chlamydia trachomatis in vitro. J Antimicrob Chemother. 1979 Jul;5(4):483–484. doi: 10.1093/jac/5.4.483. [DOI] [PubMed] [Google Scholar]
  19. Spencer R. C., Smith T., Talbot M. D. Ceftizoxime in the treatment of uncomplicated gonorrhoea. Br J Vener Dis. 1984 Apr;60(2):90–91. doi: 10.1136/sti.60.2.90. [DOI] [PMC free article] [PubMed] [Google Scholar]
  20. Stamm W. E., Guinan M. E., Johnson C., Starcher T., Holmes K. K., McCormack W. M. Effect of treatment regimens for Neisseria gonorrhoeae on simultaneous infection with Chlamydia trachomatis. N Engl J Med. 1984 Mar 1;310(9):545–549. doi: 10.1056/NEJM198403013100901. [DOI] [PubMed] [Google Scholar]
  21. Stamm W. E., Tam M., Koester M., Cles L. Detection of Chlamydia trachomatis inclusions in Mccoy cell cultures with fluorescein-conjugated monoclonal antibodies. J Clin Microbiol. 1983 Apr;17(4):666–668. doi: 10.1128/jcm.17.4.666-668.1983. [DOI] [PMC free article] [PubMed] [Google Scholar]
  22. de Carneri I. Single drug therapy of gonorrhoea with the new cephalosporins? Lancet. 1983 Apr 9;1(8328):821–821. doi: 10.1016/s0140-6736(83)91878-0. [DOI] [PubMed] [Google Scholar]

Articles from Antimicrobial Agents and Chemotherapy are provided here courtesy of American Society for Microbiology (ASM)

RESOURCES