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. 1986 May;29(5):941–944. doi: 10.1128/aac.29.5.941

Inhibition of herpes simplex virus type 1 replication by halothane.

E Bedows, T C Holland, P R Knight
PMCID: PMC284188  PMID: 3015010

Abstract

Halothane (2-bromo-2-chloro-1,1,1-trifluoroethane) inhibited herpes simplex virus type 1 (HSV-1) replication, although HSV-1 DNA was synthesized at normal levels in Vero cells. Viral capsids and extracellular virions were inhibited, and HSV-1 protein synthesis decreased by 50%, although no specific HSV-1 protein failed to be synthesized. Hyperbaric pressure failed to reverse the halothane-induced inhibition of HSV-1 replication.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

  1. Bedows E., Davidson B. A., Knight P. R. Effect of halothane on the replication of animal viruses. Antimicrob Agents Chemother. 1984 Jun;25(6):719–724. doi: 10.1128/aac.25.6.719. [DOI] [PMC free article] [PubMed] [Google Scholar]
  2. Bedows E., Knight P. R. Pressure reversal of halothane's antiviral effect. Anesthesiology. 1983 Aug;59(2):109–112. doi: 10.1097/00000542-198308000-00007. [DOI] [PubMed] [Google Scholar]
  3. Eyring H., Woodbury J. W., D'Arrigo J. S. A molecular mechanism of general anesthesia. Anesthesiology. 1973 May;38(5):415–424. doi: 10.1097/00000542-197305000-00001. [DOI] [PubMed] [Google Scholar]
  4. Franks N. P., Lieb W. R. Molecular mechanisms of general anaesthesia. Nature. 1982 Dec 9;300(5892):487–493. doi: 10.1038/300487a0. [DOI] [PubMed] [Google Scholar]
  5. Gibson W., Roizman B. Proteins specified by herpes simplex virus. 8. Characterization and composition of multiple capsid forms of subtypes 1 and 2. J Virol. 1972 Nov;10(5):1044–1052. doi: 10.1128/jvi.10.5.1044-1052.1972. [DOI] [PMC free article] [PubMed] [Google Scholar]
  6. Glorioso J. C., Levine M., Holland T. C., Szczesiul M. S. Mutant analysis of herpes simplex virus-induced cell surface antigens: resistance to complement-mediated immune cytolysis. J Virol. 1980 Sep;35(3):672–681. doi: 10.1128/jvi.35.3.672-681.1980. [DOI] [PMC free article] [PubMed] [Google Scholar]
  7. Halsey M. J., Wardley-Smith B. Pressure reversal of narocsis produced by anaesthetics, narcotics and tranquillisers. Nature. 1975 Oct 30;257(5529):811–813. doi: 10.1038/257811a0. [DOI] [PubMed] [Google Scholar]
  8. JOHNSON F. H., FLAGLER E. A. Hydrostatic pressure reversal of narcosis in tadpoles. Science. 1950 Jul 21;112(2899):91–92. doi: 10.1126/science.112.2899.91-a. [DOI] [PubMed] [Google Scholar]
  9. Knight P. R., Nahrwold M. L., Bedows E. Anesthetic action and virus replication: inhibition of measles virus replication in cells exposed to halothane. Antimicrob Agents Chemother. 1980 May;17(5):890–896. doi: 10.1128/aac.17.5.890. [DOI] [PMC free article] [PubMed] [Google Scholar]
  10. LOWRY O. H., ROSEBROUGH N. J., FARR A. L., RANDALL R. J. Protein measurement with the Folin phenol reagent. J Biol Chem. 1951 Nov;193(1):265–275. [PubMed] [Google Scholar]
  11. Laemmli U. K. Cleavage of structural proteins during the assembly of the head of bacteriophage T4. Nature. 1970 Aug 15;227(5259):680–685. doi: 10.1038/227680a0. [DOI] [PubMed] [Google Scholar]
  12. Pater M. M., Hyman R. W., Rapp F. Isolation of herpes simplex virus DNA from the "hirt supernatant". Virology. 1976 Dec;75(2):481–483. doi: 10.1016/0042-6822(76)90046-5. [DOI] [PubMed] [Google Scholar]
  13. Ruyechan W. T., Morse L. S., Knipe D. M., Roizman B. Molecular genetics of herpes simplex virus. II. Mapping of the major viral glycoproteins and of the genetic loci specifying the social behavior of infected cells. J Virol. 1979 Feb;29(2):677–697. doi: 10.1128/jvi.29.2.677-697.1979. [DOI] [PMC free article] [PubMed] [Google Scholar]
  14. Terni M., Roizman B. Variability of herpes simplex virus: isolation of two variants from simultaneous eruptions at different sites. J Infect Dis. 1970 Feb;121(2):212–216. doi: 10.1093/infdis/121.2.212. [DOI] [PubMed] [Google Scholar]

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