Abstract
The in vitro activity of clofazimine against 80 isolates of rapidly growing nonchromogenic mycobacteria was studied by an agar dilution method. The drug inhibited 96% of strains tested at concentrations less than or equal to 1 microgram/ml, and it appears to be an agent of potential efficacy against Mycobacterium fortuitum and M. chelonae.
Full text
PDF
Selected References
These references are in PubMed. This may not be the complete list of references from this article.
- Anderson R. Enhancement by clofazimine and inhibition by dapsone of production of prostaglandin E2 by human polymorphonuclear leukocytes in vitro. Antimicrob Agents Chemother. 1985 Feb;27(2):257–262. doi: 10.1128/aac.27.2.257. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Damle P., McClatchy J. K., Gangadharam P. R., Davidson P. T. Antimycobacterial activity of some potential chemotherapeutic compounds. Tubercle. 1978 Jun;59(2):135–138. doi: 10.1016/0041-3879(78)90016-8. [DOI] [PubMed] [Google Scholar]
- Gangadharam P. R., Candler E. R. Activity of some antileprosy compounds against Mycobacterium intracellulare in vitro. Am Rev Respir Dis. 1977 Apr;115(4):705–708. doi: 10.1164/arrd.1977.115.4.705. [DOI] [PubMed] [Google Scholar]
- Karat A. B., Jeevaratnam A., Karat S., Rao P. S. Controlled clinical trial of clofazimine in untreated lepromatous leprosy. Br Med J. 1971 Nov 27;4(5786):514–516. doi: 10.1136/bmj.4.5786.514. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Karat A. B., Jeevaratnam A., Karat S., Rao P. S. Double-blind controlled clinical trial of clofazimine in reactive phases of lepromatous leprosy. Br Med J. 1970 Jan 24;1(5690):198–200. doi: 10.1136/bmj.1.5690.198. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Silcox V. A., Good R. C., Floyd M. M. Identification of clinically significant Mycobacterium fortuitum complex isolates. J Clin Microbiol. 1981 Dec;14(6):686–691. doi: 10.1128/jcm.14.6.686-691.1981. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Swenson J. M., Thornsberry C., Silcox V. A. Rapidly growing mycobacteria: testing of susceptibility to 34 antimicrobial agents by broth microdilution. Antimicrob Agents Chemother. 1982 Aug;22(2):186–192. doi: 10.1128/aac.22.2.186. [DOI] [PMC free article] [PubMed] [Google Scholar]