Abstract
YTR 830, a new beta-lactamase inhibitor, combined with amoxicillin or carbenicillin, showed a synergistic effect similar to that observed with clavulanic acid, and generally better than that with sulbactam, against strains harboring chromosome-encoded penicillinases and broad-spectrum beta-lactamases or plasmid-determined beta-lactamases. With ampicillin, YTR 830 showed the best synergistic activity of the inhibitors against Proteus morganii, Citrobacter freundii, and Enterobacter cloacae and their mutants with a derepressed chromosome-encoded cephalosporinase.
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Selected References
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- Aronoff S. C., Jacobs M. R., Johenning S., Yamabe S. Comparative activities of the beta-lactamase inhibitors YTR 830, sodium clavulanate, and sulbactam combined with amoxicillin or ampicillin. Antimicrob Agents Chemother. 1984 Oct;26(4):580–582. doi: 10.1128/aac.26.4.580. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gutmann L., Kitzis M. D., Acar J. F. Sch 34343 activity against streptococci and beta-lactam-resistant Enterobacteriaceae. J Antimicrob Chemother. 1985 Jun;15 (Suppl 100):147–154. doi: 10.1093/jac/15.suppl_c.147. [DOI] [PubMed] [Google Scholar]
- Hart C. A., Percival A. Resistance to cephalosporins among gentamicin-resistant klebsiellae. J Antimicrob Chemother. 1982 Apr;9(4):275–286. doi: 10.1093/jac/9.4.275. [DOI] [PubMed] [Google Scholar]
- Philippon A., Thabaut A., Meyran M., Nevot P. Distribution des bêta-lactamases constitutives chez Pseudomonas aeruginosa. Presse Med. 1984 Mar 29;13(13):772–776. [PubMed] [Google Scholar]
- Richmond M. H., Sykes R. B. The beta-lactamases of gram-negative bacteria and their possible physiological role. Adv Microb Physiol. 1973;9:31–88. doi: 10.1016/s0065-2911(08)60376-8. [DOI] [PubMed] [Google Scholar]
- Yamaguchi A., Hirata T., Sawai T. Kinetic studies on inactivation of Citrobacter freundii cephalosporinase by sulbactam. Antimicrob Agents Chemother. 1983 Jul;24(1):23–30. doi: 10.1128/aac.24.1.23. [DOI] [PMC free article] [PubMed] [Google Scholar]