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. Author manuscript; available in PMC: 2010 Mar 19.
Published in final edited form as: Lupus. 2008 Oct;17(10):931–936. doi: 10.1177/0961203308094994

Figure 1.

Figure 1

Different mechanisms explaining aPL-induced TF expression. Antibodies against β2GPI induce TF expression on endothelial cells (A) and on circulating blood monocytes (B). The activation of complement can cause an increase in the expression of functionally active TF. Complement split product C5a induces TF expression in leukocytes (monocytes and neutrophils) and on endothelial cells (D). The terminal or membrane attack complex (MAC) activates endothelial cells resulting in expression of TF (E).