Abstract
The penetration of ofloxacin was studied in 22 patients with purulent meningitis or ventriculitis treated with conventional antibiotics. Three successive doses of 200 mg were infused at 12-h intervals during the acute stage of the disease. Ten patients received three additional doses when the meninges were considered to be healed. Cerebrospinal fluid (CSF) was drawn 0.5, 3, 6, or 12 h after the last infusion. Serial plasma and CSF samples were also obtained from patients with ventricular drainage. Concentrations in CSF ranged from 0.96 +/- 0.15 to 1.80 +/- 0.29 microgram/ml, depending on sampling time. The percentage of penetration in ventricular fluid, expressed as the ratio of the CSF area under the curve from 0 to 12 h to the plasma area under the curve from 0 to 12 h, was 73 +/- 6. Ofloxacin readily diffuses into CSF of patients with meningitis or ventriculitis and may be useful for treatment of CSF infections caused by susceptible pathogens.
Full text
PDFSelected References
These references are in PubMed. This may not be the complete list of references from this article.
- Buckwold F. J., Hand R., Hansebout R. R. Hospital-acquired bacterial meningitis in neurosurgical patients. J Neurosurg. 1977 Apr;46(4):494–500. doi: 10.3171/jns.1977.46.4.0494. [DOI] [PubMed] [Google Scholar]
- Drancourt M., Gallais H., Raoult D., Estrangin E., Mallet M. N., De Micco P. Ofloxacin penetration into cerebrospinal fluid. J Antimicrob Chemother. 1988 Aug;22(2):263–265. doi: 10.1093/jac/22.2.263. [DOI] [PubMed] [Google Scholar]
- Hooper D. C., Wolfson J. S. The fluoroquinolones: pharmacology, clinical uses, and toxicities in humans. Antimicrob Agents Chemother. 1985 Nov;28(5):716–721. doi: 10.1128/aac.28.5.716. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Kumada T., Neu H. C. In-vitro activity of ofloxacin, a quinolone carboxylic acid compared to other quinolones and other antimicrobial agents. J Antimicrob Chemother. 1985 Nov;16(5):563–574. doi: 10.1093/jac/16.5.563. [DOI] [PubMed] [Google Scholar]
- Stahl J. P., Croize J., Lefèbvre M. A., Bru J. P., Guyot A., Leduc D., Fourtillan J. B., Micoud M. Diffusion of ofloxacin into the cerebrospinal fluid in patients with bacterial meningitis. Infection. 1986;14 (Suppl 4):S254–S255. doi: 10.1007/BF01661286. [DOI] [PubMed] [Google Scholar]
- Stübner G., Weinrich W., Brands U. Study of the cerebrospinal fluid penetrability of ofloxacin. Infection. 1986;14 (Suppl 4):S250–S253. doi: 10.1007/BF01661285. [DOI] [PubMed] [Google Scholar]
- Täuber M. G., Sande M. A. Principles in the treatment of bacterial meningitis. Am J Med. 1984 May 15;76(5A):224–230. doi: 10.1016/0002-9343(84)90268-7. [DOI] [PubMed] [Google Scholar]
- Wolff M., Regnier B., Daldoss C., Nkam M., Vachon F. Penetration of pefloxacin into cerebrospinal fluid of patients with meningitis. Antimicrob Agents Chemother. 1984 Sep;26(3):289–291. doi: 10.1128/aac.26.3.289. [DOI] [PMC free article] [PubMed] [Google Scholar]