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. 1989 Jun;33(6):977–979. doi: 10.1128/aac.33.6.977

Biliary and pancreatic excretion of cefamandole.

G P Burns 1, T A Stein 1, M Cohen 1
PMCID: PMC284269  PMID: 2764549

Abstract

After intravenous infusion of secretin and cholecystokinin in six dogs, cefamandole (50 mg/kg of body weight) was given intravenously for 10 min. Samples of serum, bile, pancreatic juice, liver, pancreas, fat, and muscle were collected over a 2-h period. Cefamandole levels were measured by a microbiological assay. The highest levels were as follows: serum, 160 micrograms/ml; bile, 3,071 micrograms/ml; pancreatic juice, 7 micrograms/ml; liver, 101 micrograms/g; pancreas, 44 micrograms/g; muscle, 20 micrograms/g; and fat, 14 micrograms/g. Levels in pancreatic juice were extremely low compared with levels in pancreatic tissue, suggesting the existence of a barrier to excretion at the ductal membrane.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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