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. 1992 Nov;36(11):2539–2541. doi: 10.1128/aac.36.11.2539

Penetration of vancomycin in uninfected sternal bone.

L Massias 1, C Dubois 1, P de Lentdecker 1, O Brodaty 1, M Fischler 1, R Farinotti 1
PMCID: PMC284370  PMID: 1489201

Abstract

Concentrations of vancomycin in sternal bones of 10 patients undergoing cardiac surgery were studied at steady state, 48 h after starting intravenous prophylaxis. A sample of sternal bone was taken before (group I) or after (group II) cardiopulmonary bypass. The mean vancomycin concentrations in sternal bones were not significantly different between the groups and were 9.3 +/- 3.0 micrograms/g. The concentrations of vancomycin in sternal bones were always above the MICs for staphylococci, streptococci, and enterococci.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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