Abstract
It is known that daily polyaspartic acid (PAA) protects the kidney from gentamicin nephrotoxicity in a standardized rat model despite marked cortical accumulation of the aminoglycoside. The present experiments address the duration of PAA protection. When administered every other day, PAA provided functional and histologic protection against gentamicin-induced toxicity. A stepwise reduction in nephroprotection occurred as the dosage interval was prolonged.
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- Beauchamp D., Laurent G., Maldague P., Abid S., Kishore B. K., Tulkens P. M. Protection against gentamicin-induced early renal alterations (phospholipidosis and increased DNA synthesis) by coadministration of poly-L-aspartic acid. J Pharmacol Exp Ther. 1990 Nov;255(2):858–866. [PubMed] [Google Scholar]
- English J., Gilbert D. N., Kohlhepp S., Kohnen P. W., Mayor G., Houghton D. C., Bennett W. M. Attenuation of experimental tobramycin nephrotoxicity by ticarcillin. Antimicrob Agents Chemother. 1985 Jun;27(6):897–902. doi: 10.1128/aac.27.6.897. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Gilbert D. N., Wood C. A., Kohlhepp S. J., Kohnen P. W., Houghton D. C., Finkbeiner H. C., Lindsley J., Bennett W. M. Polyaspartic acid prevents experimental aminoglycoside nephrotoxicity. J Infect Dis. 1989 May;159(5):945–953. doi: 10.1093/infdis/159.5.945. [DOI] [PubMed] [Google Scholar]
- Kacew S. Inhibition of gentamicin-induced nephrotoxicity by pyridoxal-5'-phosphate in the rat. J Pharmacol Exp Ther. 1989 Jan;248(1):360–366. [PubMed] [Google Scholar]
- Kikuchi S., Aramaki Y., Nonaka H., Tsuchiya S. Effect of dextran sulfate on renal accumulation of gentamicin. Pharm Res. 1990 Jun;7(6):644–647. doi: 10.1023/a:1015830614244. [DOI] [PubMed] [Google Scholar]
- Kishore B. K., Lambricht P., Laurent G., Maldague P., Wagner R., Tulkens P. M. Mechanism of protection afforded by polyaspartic acid against gentamicin-induced phospholipidosis. II. Comparative in vitro and in vivo studies with poly-L-aspartic, poly-L-glutamic and poly-D-glutamic acids. J Pharmacol Exp Ther. 1990 Nov;255(2):875–885. [PubMed] [Google Scholar]
- Kojima R., Ito M., Suzuki Y. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (3). Protective effect of latamoxef against tobramycin nephrotoxicity and its protective mechanism. Jpn J Pharmacol. 1986 Nov;42(3):397–404. doi: 10.1254/jjp.42.397. [DOI] [PubMed] [Google Scholar]
- Kojima R., Ito M., Suzuki Y. Studies on the nephrotoxicity of aminoglycoside antibiotics and protection from these effects (9): Protective effect of inositol hexasulfate against tobramycin-induced nephrotoxicity. Jpn J Pharmacol. 1990 Jul;53(3):347–358. doi: 10.1254/jjp.53.347. [DOI] [PubMed] [Google Scholar]
- Ramsammy L. S., Josepovitz C., Lane B. P., Kaloyanides G. J. Polyaspartic acid protects against gentamicin nephrotoxicity in the rat. J Pharmacol Exp Ther. 1989 Jul;250(1):149–153. [PubMed] [Google Scholar]
- Swan S. K., Kohlhepp S. J., Kohnen P. W., Gilbert D. N., Bennett W. M. Long-term protection of polyaspartic acid in experimental gentamicin nephrotoxicity. Antimicrob Agents Chemother. 1991 Dec;35(12):2591–2595. doi: 10.1128/aac.35.12.2591. [DOI] [PMC free article] [PubMed] [Google Scholar]
- Williams P. D., Hottendorf G. H. Inhibition of renal membrane binding and nephrotoxicity of gentamicin by polyasparagine and polyaspartic acid in the rat. Res Commun Chem Pathol Pharmacol. 1985 Feb;47(2):317–320. [PubMed] [Google Scholar]