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. 1994 Jan;38(1):126–129. doi: 10.1128/aac.38.1.126

Effect of mycophenolic acid on Epstein-Barr virus infection of human B lymphocytes.

C Alfieri 1, A C Allison 1, E Kieff 1
PMCID: PMC284407  PMID: 8141564

Abstract

The effect of mycophenolic acid (MPA) on the growth of Epstein-Barr virus (EBV)-transformed B cells and on EBV lytic-cycle gene expression was investigated. MPA inhibited the proliferation of newly infected or established EBV-transformed B-cell lines but was not able to block cell growth transformation or the viral lytic cycle. These results suggest that MPA might reduce transformed-cell proliferation in transplant patients and possibly decrease the risk of development of EBV-related lymphoproliferative disorders.

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Selected References

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