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. 1994 Jan;38(1):144–146. doi: 10.1128/aac.38.1.144

Comparative activities of piperacillin and tazobactam against clinical isolates of Legionella spp.

L A Collins 1, C B Wennersten 1, M J Ferraro 1, R C Moellering Jr 1, G M Eliopoulos 1
PMCID: PMC284412  PMID: 8141570

Abstract

We evaluated the in vitro activity of piperacillin alone or in combination with the beta-lactamase inhibitor tazobactam against clinical isolates of Legionella species. At an inoculum of approximately 10(4) CFU, tazobactam, piperacillin, and the 8:1 combination had equivalent activities against Legionella spp. At an approximately 10-fold higher inoculum, the following results were obtained, expressed as MICs for 50 and 90% of strains tested (MIC range): piperacillin, 4 and 16 (0.25 to 32) micrograms/ml; tazobactam, 0.5 and 1 (0.125 to 2) micrograms/ml; and piperacillin-tazobactam (expressed in terms of MIC of piperacillin) 0.5 and 1 (0.03 to 2) micrograms/ml. Tazobactam alone and the combination with piperacillin were more active than piperacillin alone at the higher inoculum.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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