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. 1994 Jan;38(1):147–150. doi: 10.1128/aac.38.1.147

Treatment of Klebsiella pneumoniae septicemia in normal and leukopenic mice by liposome-encapsulated muramyl tripeptide phosphatidylethanolamide.

P M Melissen 1, W van Vianen 1, I A Bakker-Woudenberg 1
PMCID: PMC284413  PMID: 8141571

Abstract

The effect of free muramyl tripeptide phosphatidylethanolamide (MTPPE) and liposome-encapsulated MTPPE (LE-MTPPE) on Klebsiella pneumoniae septicemia resulting from intraperitoneal bacterial inoculation was investigated in mice. When administering a single prophylactic dose at 24 h before bacterial inoculation, the percentage survival was 55% (MTPPE) or 40% (LE-MTPPE), whereas untreated control mice died. Only repeated prophylactic treatment with LE-MTPPE could further increase survival up to 85%.

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Selected References

These references are in PubMed. This may not be the complete list of references from this article.

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