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. 1994 Feb;38(2):403–406. doi: 10.1128/aac.38.2.403

(6S)-6-fluoroshikimic acid, an antibacterial agent acting on the aromatic biosynthetic pathway.

G M Davies 1, K J Barrett-Bee 1, D A Jude 1, M Lehan 1, W W Nichols 1, P E Pinder 1, J L Thain 1, W J Watkins 1, R G Wilson 1
PMCID: PMC284469  PMID: 8192477

Abstract

(6S)-6-Fluoroshikimic acid inhibited the growth of Escherichia coli B on minimal medium (MIC, 0.25 micrograms ml-1), and it protected mice challenged intraperitoneally with the same organism (50% protective dose, 0.06 mg kg of body weight-1). We propose that inhibitors of bacterial aromatic biosynthesis have the potential for use in human medicine.

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Selected References

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