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Partial silencing of PPARδ reduces calreticulin and increases GLUT-1 expression in VECs. Subconfluent cultures of VECs maintained at 25 mmol/l glucose were transfected with siRNA targeted to the bovine PPARδ mRNA, as described under research design and methods and incubated for 72 h. The cultures were then washed, lysed, and taken for Western blot analyses of PPARδ (A), calreticulin (B), and GLUT-1 (C). *P < 0.05, for differences from the metafectene controls (n = 4).
